Cop: How the new coronavirus "changed" to escape the immune system 'attack'

Pharma Network February 8 - The battle between humans and the new coronavirus continues.
the pressure of the body's immune system to "surround" the virus is also evolving.
new study published in the American journal Science suggests that the new coronavirus can evade the immune system by constantly "transforming".
The study, conducted by researchers at the University of Pittsburgh School of Medicine and others, found that the new coronavirus was able to selectively remove tiny fragments of its genetic sequence, which occurred in the position of the prickly protein responsible for encoding it, resulting in a change in the shape of the hedgehog protein, making it difficult to "capture" neutralized antibodies that had not seen the "new appearance" of the hedgehog protein.
new coronavirus infects human cells mainly through its surface prick protein in combination with the "angiotensin-converting enzyme 2 (ACE2)" complex, making the python a key target for new coronary vaccine and drug development.
study also found that changes in the shape of the prickly protein did not cause the new coronavirus to lose its ability to invade cells and multiply.
, because deleted fragments cannot be found by the viral protease responsible for "proofreading" during virus gene replication, such mutations are cured in viral genetic information.
researchers first isolated a sample of a missing gene sequence from a new patient with immunodeficiency, and later, by analyzing the global database of new coronavirus sequences, found that during virus evolution, the deletion of such gene fragments continued to occur in the area where the gene sequence was responsible for encoding the pyrethroid protein.
, for example, the recent discovery of a mutant new coronavirus in the UK has resulted in the removal of genetic fragments.
the extent to which this "variant" of the virus breaks through the immune system barrier remains to be seen, the researchers said.
But if the virus evolves like this, it may affect the effectiveness of existing vaccines and therapies, so people need to rely on a variety of ways to fight the virus, such as developing different antibody combinations, different types of vaccines, and so on.