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The study also uncovered an innovative strategy to reduce plaqu.
Published data suggest that rapamycin may also improve learning and memory in aged mic.
Dr Manzoor Bhat, the study's senior author, said: "Trem2 is a receptor on the surface of microglia that enables these cells to phagocytose and degrade beta-amyloi.
drug target
Importantly, the study, recently published in the Journal of Neuroscience, also suggests a new way to increase Trem2 in microgli.
Previous studies have shown that deletion of Tsc1 leads to activation of the mTOR (mammalian target of rapamycin) signaling pathwa.
The experiments were performed in a specific mouse strain called 5XFAD, which is used as a model for Alzheimer's disease in human.
more investigation
The study's results may give the medical community a reason to suspend testing of rapamycin for anyone at risk of Alzheimer's diseas.
The Bhat lab specializes in creating and analyzing genetic models of human diseas.
Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model
