Comparison of the protective effects of Periplaneta americana and its different extracts on acute immune liver injury

Recently, researchers from the Department of Gastroenterology, the Second Affiliated Hospital of Anhui Medical University published a paper to explore the protective effect of Periplaneta americana and its different extracts on the liver function in mice with acute immune liver injury induced by concanavalin A (ConA) The results showed that Periplaneta americana and its extract had a protective effect on ConA induced acute immune liver injury in mice There was difference in efficacy between Periplaneta americana and its extract The effect of insect powder suspension group and water extract group was better than that of alcohol extract group and alcohol water double extract group This article was published in the Journal of Anhui Medical University, the first issue in 2014 The mice were randomly divided into normal control group, model group, insect powder suspension group (100, 200 mg / kg), alcohol extraction group (100, 200 mg / kg), water extraction group (100, 200 mg / kg), alcohol water double extraction group (100, 200 mg / kg), biphenyl ester group (200 mg / kg) After 10 days of intragastric administration of Periplaneta americana powder and its different extracts, ConA 20 mg / kg was injected into tail vein to prepare acute immune liver injury model After h, the weight of mice was weighed, the activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum was measured with blood taken from eyeball; the liver and spleen of mice were taken out and weighed, and the index of liver and spleen was calculated; the activity of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH) in liver homogenate was measured and the histopathological changes of liver were observed with HE staining Compared with the model group, the administration group decreased the liver spleen index (P < 0.01, P < 0.05) of mice with acute immune liver injury induced by ConA, decreased the activities of ALT and AST in serum (P < 0.01, P < 0.05), MDA in liver tissue (P < 0.01, P < 0.05), increased the activities of SOD and GSH in liver tissue (P < 0.01, P < 0.05), and alleviated the pathological damage of mice liver.