Common Click Reactions and their reagents, CuAAC

Click chemistry, also translated as link chemistry, speed mating combination chemistry
.

It has been well applied in many fields such as development, optimization of biomedical materials, biomolecular labeling and detection, and has become one
of the hot research fields.

Click Chemistry conforms to the 12 principles of green chemistry and has the following characteristics: raw materials are easy to obtain; The reaction operation is simple, the conditions are mild, and it is not sensitive to oxygen and water; High product yield and good selectivity; The product is easy to purify and simple in post-processing; By-products are harmless
.

CuAAC is one
of the common Click reactions.

Sharpless et al.
and Meldal et al.
independently discovered in 2002 that, in the presence of reducing agents and/or stable ligands, a cycloal addition reaction occurs between azides and alkynes under copper (I) catalysis to form a stable triazole moiety similar to an amide bond [1,4-disubstitution (trans)-1,2,3-triazole], called the CuAAC reaction
.

The reaction has high efficiency and relatively rapid kinetics, and has been applied to bioconjugating and organic synthesis, including labeling/imaging of biomolecules (such as proteins, glycans, lipids, nucleic acids), and the generation of bioactive molecular analogue libraries
.

Xi'an Kaixin Biotechnology Co.
, Ltd.
provides a variety of CuAAC reaction reagents: Xi'an Kaixin Biotechnology Co.
, Ltd.
is a domestic industry PEG supplier, can provide PEG derivatives of different molecular weights, the circulation of small molecule PEG nodes can be done 1-36, polymer PEG molecular weight from 1000-40000 range, can be modified groups are: amino, NHBOC, Fmoc, carboxylic acid, Mal, NHS, azide , DBCO class, Cy3/ Cy5 / Cy7 class, THP class, benzyl class, propyne group, brominated class, tert-butyl propionate class, tert-butyl acetate class, methyl group, sulfonate, mercapto class, product purity of up to 98% or more, our company with the industry technology, integrity management and continuous innovation spirit and development and growth, while developing at the same time do not forget to constantly summarize and optimize the service for customers, depending on customer success as their responsibility, and strive to dedicate products, quality services
。
Supplier: Xi'an Kaixin Biotechnology Co.
, Ltd.
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, Ltd.
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, Ltd.
to view the azide compound 1, bifunctional reagent (bioconjugated) with amine, carboxyl/carbonyl or mercapto react, and add (or label) azide groups
to the target (biological) molecule.

Chemically selective reaction with terminally labeled alkynes (via CuAAC or SPAAC, respectively) to add amines, carboxyl/carbonyl or mercapto functional groups
to the target (biological) molecule.

Azidoacetic Acid NHS Ester Azidoacetic Acid NHS Ester 824426-32-6Azido-PEG4-NHS Ester Azido-PEG4-NHS Ester 944251-24-5Azidoacetic Acid Azidoacetic Acid 18523-48-3 Azidohexanoic acid, 97% 6-Azidohexanoic acid 79598-53-1Azido-PEG4-acid azido-PEG4-acid 1257063-35-63-Azidopropylamine, 3-Azidopropylamine 88192-19-22, biotinylation reagent (for separation) by click reaction, these cleavable and non-cleavable reagents are used to label alkyne-labeled modified biomolecules and biotin for streptavidin affinity
purification.

Biotin Azide Azide Biotin 908007-17-0Biotin-PEG3-Azide, Biotin-PEG3-Azide 875770-34-6Desthiobiotin-PEG3-Azide, Desulfurized Biotin-PEG3-Azide 3, Azido-1, 3-dimethylimidazolinium Hexafluorophosphate2-azido-1,3-dimethylimidazolium hexafluorophosphate 1266134-54-6A2457Lithium azide, 20 wt.
% solution in H2O lithium azide, 20 wt.
% aqueous solution 19597-69-4430411 Tetratrabutylammonium Azide tetrabutylammonium tetrabutylammonium tetrabutylammonium 993-22-6T09204, Other reagents 5-Azido-UTP Triethylamine Salt 5-azido-UTP triethylamine salt 105518-68-1Boc-4-azido-L-phenylalanine Boc-4-azido-L-phenylalanine 33173-55-6Fluorescein biotin 134759-22-15, DBCO DBCO-COOH, 1353016-70-2DBCO-C6-COOH,CAS:1425485-72-8DBCO-C6-NHS Ester,1384870-47-6DBCO-NH2,CAS:1255942-06-3DBCO-NHS,CAS:1353016-71-3DBCO-MAL,1395786-30-7DBCO-PEG-DBCO, 10KDBCO-PEG4-NHS,CAS:1427004-19-0DBCO-PEG-NHS,MW:2000DBCO-PEG-NH2,MW:2000 Or more information is provided by Xi'an Kaixin Biotechnology Co.
, Ltd.
, all of the above reagents are for scientific research purposes
only.