Collection: BmJ Research Highlights on October 19, 2019

1Amoxicillin for the treatment of chronic back paindoi: https://doi.org/10.1136/bmj.l5654recently researchers examined the effectiveness of three-monthantibiotic
treatment for chronic back pain, disc protrusion, and vertebral final plate change (modic change)thestudy was conducted in Norway, involving 180 patients with chronic back pain, expaste disc protrusion, and type 1 or 2 ModiC, and randomly received 750 mg of amocilinin or a placebo three times a day for three monthsThe main endpoint of the study was the Roland Morris Disability Questionnaire (RMDQ) score changesIn the preliminary analysis of the overall cohort, the difference in average RMDQ scores between amoxicillin and placebo groups was -1.6, and 50 patients in the Amoxicillin group (56%) had at least one adverse drug-related reaction, compared with 31 (34%) in the placebo group: The relationship between preterm birth and poor perinatal caredoi: https://doi.org/10.1136/bmj.l5678researchers recently examined the relationship between preterm birth or delivery in non-tertiary hospitals and poor perinatal outcomesborn between 2008 and 2015, extremely premature babies under 28 weeks of pregnancy (n-17577) are grouped according to the hospital of birth and the transfer within 48 hours of birth: transfer to a higher level (non-level-three hospitals, n-2158), non-tertiary care (born in a non-tertiary hospital; non-transfer, n-2668) and control (born in a tertiary hospital, n0866)The main endpoint of the study was death, severe brain damage, survival and no serious brain injuryCompared to the control group, infants transferred to higher hospitals had no significant difference in pre-hospital mortality (OR:1.22), but the rate of severe brain injury increased significantly (2.32; the number of people requiring treatment (NNT) was 8), and the survival rate of no severe brain injury was significantly reduced (0.60; NNT 9) Compared to the control group, the infant mortality rate increased (1.34) in the non-tertiary care group, but there was no significant difference in survival rates for severe brain injury (0.95) or no severe brain injury (0.82) There was no significant difference in pre-hospital mortality (1.10) in non-tertiary care groups compared to infants in the transfer group to a higher level, but the incidence of severe brain injury (0.41; NNT 8) decreased significantly and the survival rate of no severe brain injury (1.37; NNT 14) increased significantly Weight Change and Risk of Death : https://doi.org/10.1136/bmj.l5584 researchers recently examined the relationship between weight changes and mortality in adulthood study looked at data from the National Health and Nutrition Examination Survey (NHAES) 1988-94 and 1999-2014 36,051 persons aged 40 or over measured weight and height at the baseline and returned to their youth (25 years) and middle-aged (10 years before baseline) The main endpoint of the study was the specific mortality rate before 31 December 2015 During the 12.3 years of follow-up, 10,500 people died The overall and heart disease mortality rates for young and middle-aged people, from non-obese to obese, were 22 percent higher (HR: 1.22) and 49 percent (1.49) higher than those who remained at normal weight During this period, changes in BMI ranged from obesity to non-obesity and were not related to the risk of death From mid-to-late adulthood, the pattern of weight change from obesity to non-obesity was associated with an increase in total cause mortality (1.30) and heart disease mortality (1.48), while the transition from non-obese to obese in this period was not significantly associated with a risk of death Maintaining obesity in adulthood is consistent with the increased risk of all causes of mortality, with a risk of 1.72 in the middle of adulthood, 1.61 in late adulthood and 1.20 in the middle of adulthood to late adulthood MedSci Source: MedSci Original