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Scientists have discovered three viruses in bats in Laos.
David Robertson, a virologist at the University of Glasgow in the UK, called the discovery "fascinating and terrifying
Has the coronavirus been transmitted from animals to humans twice?
The research results have not been peer reviewed and have been published on the preprint server Research Square1
To make this discovery, Mark Eloyt, a virologist at the Pasteur Institute in Paris, and his colleagues in France and Laos took samples of saliva, feces, and urine from 645 bats in caves in northern Laos.
The origin of nature
Edward Holmes, a virologist at the University of Sydney in Australia, said: "When SARS-CoV-2 was first sequenced, the receptor binding domain was different from anything we have seen before
"I am more convinced than ever that SARS-CoV-2 has a natural origin," Linfa Wang, a virologist at the Duke University-National University of Singapore School of Medicine, agrees
Alice Latinne, an evolutionary biologist at the Wildlife Conservation Society Vietnam (Wildlife Conservation Society Vietnam), said that with the addition of SARS-CoV-2 relatives found in Thailand, Cambodia and Yunnan in southern China, this study shows that Southeast Asia is a “SARS-CoV -2 Hot spots of related virus diversity"
Coronavirus is closely related to pandemic viruses found in Japan and Cambodia
In another step of their research, Eloit and his team showed in the laboratory that the receptor binding domains of these viruses can attach to the ACE2 receptor on human cells as effectively as some early variants of SARS-CoV-2.
Last year, researchers described another close relative of SARS-CoV-2, named RaTG13, which was found in bats in Yunnan
Spyros Lytras, an evolutionary virologist at the University of Glasgow (University of Glasgow), said that viruses exchange RNA sequences with each other through a process called recombination.
The missing link
Researchers say that the Laos study provides insight into the origin of the pandemic, but there are still missing links
The study also did not clarify how the ancestors of the virus went to Wuhan in central China, nor did it say whether the virus took an intermediate animal
