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In order to better assist the clinical diagnosis and differential diagnosis of malignant liver lesions, as well as the early warning and the evaluation of the prognosis of liver cancer, the laboratory can carry out the triple test for liver cancer screening (abnormal prothrombin, alpha-fetoprotein heterogenous body and ratio)
Reference range:
Clinical significance:
(1) Screening and early diagnosis of liver cancer
Serum DCP levels were mildly elevated in patients with liver diseases other than HCC, but significantly elevated in HCC patients
(2) Treatment effect and recurrence monitoring of HCC patients
DCP-positive patients had a higher incidence of intrahepatic metastasis, portal vein invasion, hepatic venous aneurysm thrombosis, and capsular invasion, and levels >90 ng/ml were independent predictors of microvascular invasion, suggesting a poor prognosis
(3) Evaluation indicators for the prognosis of liver cancer
(4) Screening for liver cancer in physical examination population
The early symptoms of liver cancer are hidden, and high-risk groups need regular physical examinations
2.
(1) AFP-L3% helps to differentiate AFP-positive benign and malignant liver diseases
The determination of AFP-L3% is helpful for the differential diagnosis of benign and malignant liver diseases, and is not affected by AFP content
(2) Better indicators for early warning of liver cancer
AFP-L3% may increase in blood with hepatocellular carcinoma in the months or even years before the characteristic space-occupying lesions of liver cancer are detected by imaging examination
(3) AFP-L3% contributes to the evaluation of the prognosis of liver cancer
The content of AFP-L3% is related to portal vein invasion and malignant characteristics of liver cancer, especially portal vein invasion and tumor differentiation
(4) Tumor malignancy index
AFP-L3% positive HCC usually has abundant hepatic arterial blood supply, shorter tumor doubling time and higher malignancy
