Clin Transl Iael: Early Indicators for Predicting Vaccine Effectiveness

2020 May 17 News / BioValley BIOON / --- In a recent study, LMU researchers showed that compared to conventional neutralizing antibody test, a blood after vaccination Appearing specific immune cells is an indication of an early indicator of the effectiveness of the vaccineCoronavirus infectioncurrent pandemic and other pathogenic viruses that cause outbreaks of societies around the world posed a growing threat, especially when a very effective vaccine shortageTo design better vaccines, we need a better understanding of the complexity of the virus attacks the immune response and vaccine cellsIn this study, through the blood level of leukocytes in a specific measurement time prediction of the immune response induced by the vaccinationThe new findings are published in "Clinical & TranslationalImmunology" magazineThe current vaccine against yellow feverbelongs to "live vaccine", which contains intact virus particles yellow fever virus vaccine strain, but its toxicity is greatly reducedAfter vaccination, vaccine virus replication in vivo, to induce the immune system to produce specific antibodiesThese antibodies specifically bind to the virus, thereby preventing their entry into the cell and other components of the immune system destructionBaumjohann said: "In our study, we monitored the development of the blood of healthy subjects immune response." Significant effectyellow fever vaccine is attributed to the fact that: it triggers a very high level of specificity produce antibodies, such antibodies specific for decades after immunization can still be detectedHow to vaccine-induced longevity of this abnormal immune response is not fully understoodInduce antibody formation and secretion is a complex process in which cells called T follicular helper cell (of Tfh) it plays a vital rolestudies show that measurements of Tfh like cells and kinetic properties can be predicted efficacy of yellow fever vaccine-induced immune response, even before it has predicted a detectable amount of inhibition of viral replication and the appearance of antibodies effectEfficient formed after natural infection or vaccination, and antibody may take up to several weeks In contrast, about 7 days, and can be detected in the vaccine-induced T follicular helper cells in blood after vaccination (Biovalley Bioon.com) Information Source: Viralinfection: Earlyindicatorsofvaccineefficacy Original source: JohannaEHuberetal, DynamicchangesincirculatingTfollicularhelpercell compositionpredictneutralisingantibodyresponsesafteryellowfevervaccination , < br /> Clinical & TranslationalImmunology (2020) .DOI: 10.1002 / cti2.1129