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Clin Cancer Res: A new CIP2A mutant (NOCIVA) that can predict TKI resistance in myeloid leukemia

 Last Update: 2021-03-20
 Source: Internet
 Author: User

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PP2A cancer suppressor factor (CIP2A) is an oncoprotein that inhibits the tumor suppressor gene PP2A-B56a.

Recently, Eleonora et al.

CIP2A mutants were identified by 3'and 5'rapid amplification of cancer cell cDNA ends.

NOCIVA mutant

The NOCIVA mutant contains exons 1-13 and fused 349 nucleotides from intron 13.

NOCIVA is enriched in the nucleus

NOCIVA retains the ability to bind to B56a, but CIP2A is mainly a cytoplasmic protein, and NOCIVA is transferred to the nucleus.

Samples from AML and CML patients overexpress NOCIVA but not CIP2A mRNA, which indicates that alternative splicing from CIP2A to NOCIVA is common in myeloid malignancies.

The correlation between the expression level of NOCIVA/CIP2A and the prognostic survival rate of patients

In AML, high NOCIVA/CIP2A mRNA expression rate is a sign of low overall survival rate.

Eleonora et al.

Original source:

Makela Eleonora, Pavic Karolina, Varila Taru M et al.

aacrjournals.
org/content/early/2021/03/04/1078-0432.
CCR-20-3679" target="_blank" rel="noopener">Discovery of a Novel CIP2A Variant (NOCIVA ) with clinical relevance in predicting TKI resistance in myeloid leukemias in this message

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