Client Story: Inflammatory Diet Mediates Gut Microbiota and Metabolite Changes in Crohn's Disease

Crohn's disease (CD) is a type of inflammatory bowel disease (IBD), and the development of social industrialization and urbanization has resulted in changes in residents' diet, which in turn promotes the occurrence of CD

On April 19, 2022, Professor Chen Minhu, Dr.

The study included 285 healthy subjects (HCs) and 150 newly diagnosed CD patients, and their clinical data were statistically analyzed, and the Diet inflammatory index (DII) was used to assess the inflammation in the diet of HCs and CD patients.

Figure 1.

The relationship between inflammatory diet and metabolites was further analyzed by fecal metabolome, among which 6 metabolites were significantly up-regulated in the HC-pro group, mainly involved in short-chain fatty acid (SCFAs) synthesis and metabolism-related metabolic pathways

Figure 2.

Taken together, a high DII diet may not only be a risk factor for CD but may also be associated with increased CD disease activity

Professor Chen Minhu and Professor Feng Rui from the Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University are the co-corresponding authors, and doctoral students Tian Zhenyi, assistant researcher Zhuang Xiaojun and Dr.

references

Dietary inflammatory potential mediated gut microbiota and metabolite alterations in Crohn's disease: A fire-new perspective.

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The targeted metabolomics (Q300 full quantitative metabolome) in the above study was provided by Metabolomics