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CJASN: Roxastat can effectively correct anemia in non-dialysis-dependent CKD patients without increasing the risk of cardiovascular events

 Last Update: 2021-08-26
 Source: Internet
 Author: User

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Roxadustat is an effective reversible hypoxia-inducible factor-prolyl hydroxylase inhibitor, which can simulate the body's natural response to hypoxia and stimulate a coordinated erythropoiesis response, including erythropoietin production Increase, decrease of heparin level, increase of iron supply

This study aims to analyze research data on three Rocha Division for his non-dialysis dependent CKD patients with CKD-related anemia 3, evaluate Rosa orlistat vs Placebo effect and heart blood vessel safety

Heart blood vessels

The subjects in these three double-blind trials are all CKD patients with CKD-related anemia who do not require dialysis.

Cardiovascular event myocardial infarction stroke

Changes in the average hemoglobin level of the two groups of patients

A total of 4277 nondialysis-dependent CKD patients were randomly divided into rosastat group (n=2391) and placebo group (n=1886)

During weeks 28-52, compared with the placebo group, the average hemoglobin level of patients in the rosastat group improved from baseline regardless of whether salvage treatment was performed .

Risk ratio of cardiovascular events between the two groups

Compared with placebo, roxastat did not increase the risk of MACE (HR 1.

The results of this study show that rosastat can effectively increase the hemoglobin level of non-dialysis-dependent CKD patients, correct anemia, and reduce the need for blood transfusion without increasing the risk of MACE

Roxastat can effectively increase the hemoglobin level of non-dialysis-dependent CKD patients, correct anemia, and reduce the need for blood transfusion without increasing the risk of MACE

Original source:

Robert Provenzano, Lynda Szczech, Robert Leong, et al.

Efficacy and Cardiovascular Safety of Roxadustat for Treatment of Anemia in Patients with Non-Dialysis-Dependent CKD

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