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    Home > Biochemistry News > Biotechnology News > Chronic hepatitis B: base editing or a new way to treat

    Chronic hepatitis B: base editing or a new way to treat

    • Last Update: 2021-10-09
    • Source: Internet
    • Author: User
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    Article source: Medical Rubik's Cube Info

    Author: Sunshine

    Recently, Beam Therapeutics announced that pre-clinical data proves that cytosine base editor (CBE) has the potential to reduce the expression of viral markers (such as hepatitis B surface antigen HBsAg) and prevent the rebound of hepatitis B virus (HBV)


    Chronic hepatitis B is a chronic disease in which the hepatitis B virus continues to be infected for more than 6 months, and the liver undergoes varying degrees of inflammatory necrosis (or) fibrosis


    Nucleoside and nucleoside analog drugs currently used to treat hepatitis B can inhibit the hepatitis B virus, but cannot completely remove the virus from the body


    Source: Beam Therapeutics' official website

    The base editor can directly and irreversibly convert a specific DNA base into another base without causing a double-strand break


    Source: Beam Therapeutics' official website

    This preclinical in vitro studies designed to evaluate the potential treatment of chronic hepatitis B base editor


    Base editing significantly reduces the levels of HBV-related viral markers (HBsAg, HBeAg, HBV DNA, 3.


    Source: Beam Therapeutics' official website

    These data indicate that CBE can introduce permanent mutations in cccDNA and prevent HBV rebound


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