Chongqing University's He Wei team has discovered promising new antibiotics

Title: Total synthesis and antimicrobial evaluation of natural albomycins againstst clinical pathogens
Journal:
Zihua Lin, Xiaobo Xu, Sheng Zhao, Xiaohong Yang, Jian Guo, Qun Zhang, Chunmei Jing, Shawn Chen and Yun He
Published: 2018/09/04
Digital ID: 10.1038/s414 67-018-05821-1
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A recent paper published in Nature-Newsletter
states that the fungal compound penicillin 2 has the potential to become an antibiotic. The study introduced a
and further measured the in-body antibacterial activity of penicillin-2 pairs of different bacteria.are usually a class of natural substances with complex chemical structures, and synthetic synthesis (i.e., from scratch in the laboratory) is difficult. Because bacteria are resistant to specific antibiotics, researchers must constantly explore new antimicrobial compounds.has been shown to be a class of fungal compounds with antibacterial properties. The new technology discovered by He Wei and colleagues at Chongqing University in China can synthesize large quantities of penicillin, enough for the determination of antibacterial activity. The researchers found that
it is worth noting that in the antibacterial determination of methicillin-resistant Staphylococcus aureus (
) isolated strains,
however, whether penicillin 2 can become a safe and effective antimicrobial drug is still to be further tested.
summary: Development effective antimicrobial agents continues to be be great challenge, particularlyly due to the increased resistance of superbugs and frequent hospital breakouts. There is an urgent need for more potent and safer antibiotics with novel scaffolds. As historically many commercial drugs were derived from natural products, discovery of antimicrobial agents from complex natural product structures still holds a great promise. Herein, we report the total synthesis of natural albomycins δ1 (1a), δ2 (1b), and ε (1c), which validates the structures of these peptidylnucleoside compounds and allows for synthetic access to bioactive albomycin analogs. The efficient synthesis of albomycins enables extensive evaluations of these natural products against model bacteria and clinical pathogens. Albomycin δ2 has the potential to be developed into an antibacterial drug to treat Streptococcus pneumoniaeand Staphylococcus aureus infections.journal introduction:
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(Source: Science.com)