Chinese scientists have made important progress in using nanoparticles to target and identify tumors

Xinhua News Agency, Wuhan, December 4 (Reporter Tan Yuanbin) on the nanoparticles loaded to identify lilobodies, the active identification of tumors, so as to achieve targeted treatment is an important research direction of tumor treatment, but in recent years the effectiveness of this approach has been increasingly questioned. The latest research by Chinese researchers shows that it is effective to identify tumors by using nanoparticles, but its effect is obviously affected by the target modification mode.
researchers who carried out the study were Li Feng,
of the Wuhan Virus Research Institute, and Zhang Xianen,
of the China Institute of Biophysics. Recently, with the spatial addressability of protein nano cages, using controlled self-assembly and efficient click chemical reactions, they successfully achieved precise controlled modification of targeted lids on mini ferrin nano cages, and obtained six nanoparticle models with specific liant numbers and spatial distribution.
series of cellular levels and animal model experiments show that no matter what the mating parameters, the active targeting has been contributed to different degrees. Further studies show that the differences in target performance on which these ligand distribution patterns depend are related to clustering of target cell surface subjects and related factors such as intracellular swallowing and conditioning.
Li Feng said the study helps to understand and clarify the controversy over the efficacy of active targeting in oncology nanomedical science, while highlighting the importance of precision functionalization in building bion nano probes and devices. The results of the research have recently been published online in the internationally renowned multidisciplinary journal Small.