Chinese scientists discover the guiding molecule of radiation migration in the cerebral cortex

recently,Chinese researchers have discovered that a secretion-oriented molecule of gradient expression directs the radioactive migration of neurons in the cerebral cortexThe findings help to better understand how highly ordered cerebral cortex structures are formed,provide new ideas and pathways for studying theof brain development disorders anddisordersThe findings, by researchers from the Institute of Neuroscience of the Chinese Academy of Sciences, have been published in the recently published international academic journal Nature NeuroscienceThe regulation mechanism of neuron migration in the cerebral cortex is a major problem that has not been solved in developmental neurobiologyIt is generally believed that,theof the migration of new cone neurons from the hairregion to the upper layer of the cortex,dependent on the guidance of radioactive glial fibersMoreover,, the formation of the the structure of the cerebral cortex is influenced by the adhesion and disengage mechanism of the migrating neurons and glial fibers For a long time, another potential regulatory mechanism, the concentration gradient of secretion molecules, has long been overlooked to guide the radioactive migration of the cortex neurons Researchers chen , , And Kim Ming, of the Institute of Neuroscience of the Chinese Academy of Sciences, used "gene electromagnetizing technology in the womb" to observe the migration of a group of cortist neurons in the body over a long period of time They found that by blocking signals from the secretive-oriented molecule Semaphorin-3A, the body can cause the migration to stall and be accompanied by neuronal disarray In vitro experiments have also found that the concentration gradient of endogenous Semaphorin-3A is necessary for the correct migration of new neurons and plays an attractive and guiding role These studies have shown that the radiation migration of neurons is guided by extracellular-oriented molecules This migration-oriented hypothesis helps people to better understand how highly ordered cortex structures are formed, thus providing new ideas and ways to study the of brain development disorders and diseases Reporters learned that the research work has been of the Chinese Academy of Sciences, the Ministry of Science and Technology of the , the National Natural Science Foundation of China and the Shanghai Science and Technology Commission