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The State Key Laboratory of Respiratory Diseases of Guangzhou Medical University announced on February 23 that the team of Professor Zhao Jincun of the laboratory has cooperated with Shenzhen Huada Life Sciences Research Institute and other units to find that patients with new coronary pneumonia at different time points and different physiological parts (respiratory tract, The gastrointestinal) virus quasispecies mutation and evolution characteristics provide important theoretical guidance for the evolution of the new coronavirus and the emergence of mutant strains.
Related papers were published online in the professional journal "Genome Medicine" on February 23, 2021.
The new coronavirus is highly pathogenic and spreads quickly from person to person.
It is of great significance to clarify the mutation characteristics of the new coronavirus for epidemic prevention and control, pathogen detection, and vaccine development.
The above study collected samples of patients with new coronary pneumonia at consecutive time points and multiple types, including: nasopharyngeal swabs, sputum, stool, urine, gastric mucosa, etc.
, using transcriptome sequencing and probe hybrid capture methods to simultaneously carry out the new coronavirus genome Deep sequencing to compare and analyze the evolutionary characteristics of viruses in different individuals and different tissues within individuals.
The study found that the proportion of virus-related sequences in clinical samples deep-sequencing has a certain correlation with the fluorescence quantitative CT value.
Among them, the virus-related sequences detected in respiratory tract (nose, pharynx, sputum) and intestinal samples (feces, anal swabs) are much higher than urine Fluid and gastric mucosa samples.
In addition, studies have found that there are multiple different branch viruses co-existing in the intestinal samples of patients with new coronary pneumonia, which may be caused by multiple subtypes co-infection, repeated mutations, or quasi-species changes.
In addition, the research team's comparative analysis found that the diversity of new coronaviruses in intestinal samples is higher than that in respiratory samples.
The mutations of new coronaviruses in intestinal samples are more stable, the mutation diversity is richer, and the few base mutations in individuals are more sustainable.
The relevant person in charge of the research team said that "whether intestinal samples are more likely to produce mutant strains" is an important research direction in the future, and eventually more research is needed to clarify whether or not.
According to reports, the main research areas of the State Key Laboratory of Respiratory Diseases of Guangzhou Medical University are aimed at clinical and basic research on respiratory diseases: sudden major respiratory infectious diseases and lung injury, bronchial asthma and chronic cough, chronic obstructive pulmonary disease, lung cancer Wait.
The founding director is Zhong Nanshan, an academician of the Chinese Academy of Engineering.
The link to the paper: https://genomemedicine.
biomedcentral.
com/articles/10.
1186/s13073-021-00847-5 2020 hot articles selection 1.
Cup! A full paper cup of hot coffee, full of plastic particles.
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Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
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NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
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New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
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The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
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Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the fatal changes do not occur in the brain, but in the intestines.
.
.
9.
The ultra-large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight, and restored the old brain to a young state.
.
.
Related papers were published online in the professional journal "Genome Medicine" on February 23, 2021.
The new coronavirus is highly pathogenic and spreads quickly from person to person.
It is of great significance to clarify the mutation characteristics of the new coronavirus for epidemic prevention and control, pathogen detection, and vaccine development.
The above study collected samples of patients with new coronary pneumonia at consecutive time points and multiple types, including: nasopharyngeal swabs, sputum, stool, urine, gastric mucosa, etc.
, using transcriptome sequencing and probe hybrid capture methods to simultaneously carry out the new coronavirus genome Deep sequencing to compare and analyze the evolutionary characteristics of viruses in different individuals and different tissues within individuals.
The study found that the proportion of virus-related sequences in clinical samples deep-sequencing has a certain correlation with the fluorescence quantitative CT value.
Among them, the virus-related sequences detected in respiratory tract (nose, pharynx, sputum) and intestinal samples (feces, anal swabs) are much higher than urine Fluid and gastric mucosa samples.
In addition, studies have found that there are multiple different branch viruses co-existing in the intestinal samples of patients with new coronary pneumonia, which may be caused by multiple subtypes co-infection, repeated mutations, or quasi-species changes.
In addition, the research team's comparative analysis found that the diversity of new coronaviruses in intestinal samples is higher than that in respiratory samples.
The mutations of new coronaviruses in intestinal samples are more stable, the mutation diversity is richer, and the few base mutations in individuals are more sustainable.
The relevant person in charge of the research team said that "whether intestinal samples are more likely to produce mutant strains" is an important research direction in the future, and eventually more research is needed to clarify whether or not.
According to reports, the main research areas of the State Key Laboratory of Respiratory Diseases of Guangzhou Medical University are aimed at clinical and basic research on respiratory diseases: sudden major respiratory infectious diseases and lung injury, bronchial asthma and chronic cough, chronic obstructive pulmonary disease, lung cancer Wait.
The founding director is Zhong Nanshan, an academician of the Chinese Academy of Engineering.
The link to the paper: https://genomemedicine.
biomedcentral.
com/articles/10.
1186/s13073-021-00847-5 2020 hot articles selection 1.
Cup! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the fatal changes do not occur in the brain, but in the intestines.
.
.
9.
The ultra-large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight, and restored the old brain to a young state.
.
.
