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Pictured is the adaptive immune response and immune memory build-up of SARS-CoV-2 infection in COVID-19 patients.
HA University of Technology to provide Harbin University of Technology announced on the 18th, the university's Professor Huang Zhiwei team on the new crown pneumonia of the latest research results, with "new coronary pneumonia severe and mild patients on the new coronavigic virus infection adaptive immune response" published online in the "Signal transduction and targeted treatment" magazine.
the study is important for understanding the pathogenesis and rehabilitation mechanisms of patients with new coronary pneumonia, as well as for designing vaccines and therapeutic drugs to combat SARS-CoV-2 infection.
In order to study the adaptive immune response mechanism for SARS-CoV-2 infection in COVID-19 patients and the immune memory establishment in recovered patients, the team first studied the response mechanism of adaptive immune cells in the outer blood of COVID-19 patients with different severity of the disease.
The study first found an increase in the proportion of killer T-cell sub-groups expressing cytotoxic molecules in COVID-19 patients compared to healthy people, suggesting that the proliferation of these killer T-cells was associated with COVID-19, and found a significant decrease in mucous membrane-related constant T lymphocytes in COVID-19 patients, which showed that adaptive immune systems in COVID-19 patients did not fully recover in the early stages of recovery.
addition, this study also found that the antiviral response of different COVID-19 patients is very heteroglyte, but also suggests the possibility of different antiviral response mechanisms in different individuals, which raises more possibilities for subsequent larger-scale cohort studies.
this study is important for understanding the pathogenesis and rehabilitation mechanisms of patients with severe and mild coronary pneumonia, as well as for the design of vaccines and therapeutic drugs to combat SARS-CoV-2 infections.
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