Chinese scholars find anti-new crown all-human source nanoantibodies could be developed into new drugs

Medicine Network On May 28th, reporters learned that Fudan University School of Basic Medicine Professor Tianlei and other researchers found a series of anti-new coronary whole-human source nanoantibodies, for the development of new coronavirus drugs and treatment programs are of great significancethe results have been published in the latest issue of the journal Cell Hosts and Microbesnew coronavirus has infected millions of people around the world, there is no specific drug, so the urgent need to develop safe and effective antiviral antibodiesProfessor Tian Lei said that the whole human source refers to the antibody gene all from human sonsIn recent years, a new type of antibody called "nanoantibodies" because of its small molecular weight, low production costs, stable properties, by the pharmaceutical industryHowever, nanoantibodies come from camels or alpacas, even after humanization still contains a certain amount of camel source components, making its human use there is a security riskto solve the problem of safety hazards, Yingtianlei research team and partners developed a new technology, the first to design a natural embryo gene of the all-human source nanoantibodyHigh affinity, both low cost, fast production, easy to purify, etc, is the characteristics of this kind of all-human source nanoantibodiesdue to its small size and excellent physical and chemical properties, this kind of whole-human nanoantibodies can be developed as atomized inhalation agents, a large number of antibodies are quickly transported to the lesions such as alveoliIn theory, it is particularly suitable for the treatment of respiratorysuch as new coronary pneumonia, MrYing saidusing this new technology, the research team successfully screened dozens of all-human-sourced nanoantibodies for the new coronavirus receptor binding area, two of which can be powerful and new coronavirus whole-human source nanoantibodies, can target the virus S protein's special hidden epitope(Complete)