Chinese scholars Cell Host & Microbe issued an article: The new coronavirus "full spectrum" neutralizing antibody 35B5 neutralizes the Omicron strain and its mechanism

Since its discovery in November last year, the SARS-CoV-2 superstrain Omicron has rapidly spread globally and has gradually replaced the previous Variants of Concern (VOCs) that were identified in Spike There are more than 30 mutations in the protein that allow it to evade immunity from most therapeutic neutralizing antibodies and some vaccines

On March 28, 2022, Zhu Yongqun's laboratory of the School of Biomedical Research, together with Deng Kai's laboratory of Sun Yat-sen University, Chen Zhiwei's laboratory of Hong Kong University, and Ye Lilin's laboratory of Army Medical University, published online at Cell Host & Microbe entitled "35B5 antibody potently neutralizes SARS- "CoV-2 Omicron by disrupting the N-glycan switch via a conserved Spike epitope" paper reports that 35B5, a full-spectrum human monoclonal antibody against SARS-CoV-2 VOCs, can potently neutralize Omicron and reveal its novel mechanism of action

The researchers found that the receptor-binding domain (RBD)-targeting mAb 35B5 not only potently neutralized previous VOCs, but also had nanomolar neutralization of Omicron

So, why did these changes not affect the targeting of Omicron by 35B5? The researchers found that the epitope (epitope) of 35B5 on Omicron RBD is invariant in different VOCs, and the highly conserved epitope is the molecular basis for 35B5 targeting Omicron and other VOCs RBD

This work shows that 35B5's full-spectrum potent neutralization of COVID-19 VOCs and high antigen transfer tolerance make it a good candidate for clinical treatment

Original link: https://doi.