Chinese scholars are the first to discover a new strategy to "kill" prostate cancer cells

China News Service, April 27 (Reporter Chen Jing) Prostate cancer is the most common malignant tumor of the genitourinary system.

The reporter learned on the 27th that Professor Xue Wei from the Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, and Professor Zhang Chunfu from the School of Biomedical Engineering, Shanghai Jiaotong University, have obtained new results in a joint research-the strategy of iron death triggered by exogenous heat is expected to be a treatment for prostate cancer.

According to reports, the exogenous heat-triggered iron death strategy has also been successfully implemented on kidney cancer and breast cancer cell lines.

According to reports, related results were published in the "American Chemical Society-Nano" magazine.

During the interview, the reporter learned that in recent years, inducing iron death of tumor cells has become a new strategy for anti-tumor therapy.

Researchers irradiate the tumor site with laser in situ, and use the 45°C heat generated by ferroferric oxide nanoparticles to trigger specific metabolic reprogramming and flexibly "manipulate" the "fate" of tumor cells, even if the tumor is effectively treated.

In the process, the researchers discovered relevant key regulatory factors, which is helpful to determine which type of death mode the tumor is more sensitive to, and provides mechanistic enlightenment and practical strategies for heat-induced iron death.

It is understood that this research is a cross-collaboration between the Department of Urology of Renji Hospital and the School of Biomedical Engineering, Jiaotong University, through medical-industry cross-cooperation, to give play to their respective strengths and jointly apply nanotechnology and molecular biology technologies to lay the foundation for the next step of in-depth cooperation and clinical transformation.