Figure 1 Schematic diagram of the mechanism of MG53 in preventing and treating drug-induced liver injury
Supported by the National Natural Science Foundation of China (approval numbers: 31730043, 31430043, 32000805) and other funds, the Zeng Chunyu team of the Department of Cardiovascular Medicine, Army Special Medical Center (Daping Hospital) of the Army Military Medical University and the Ohio State University Ma Jianjie team worked together to reveal Mitsugumin 53 (MG53) has a good preventive effect in drug-induced liver injury.
Drug safety is a common concern of the public, the pharmaceutical industry, regulatory agencies and doctors
The study found that MG53 (also known as Trim72) plays a vital role in cell membrane repair
This study reveals that the dual functions of MG53's membrane separation signal and cytosolic effect effectively maintain the integrity of liver cells in drug-induced liver injury, suggesting that MG53, as a myocytokine, may provide new ideas and new ideas for the prevention and treatment of drug-induced liver injury.
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