Chinese scholar Nature Aging publishes: Apolipoprotein APOE drives new activity of stem cell senescence

Apolipoprotein E (APOE), as a classic lipid-binding protein, can bind to cholesterol or other lipids to form lipoprotein particles, thereby mediating lipid transport in the central nervous system and peripheral tissues

On March 28, 2022, Liu Guanghui's research group, Qu Jing's research group, Song Mozhi's research group of the Chinese Academy of Sciences Institute of Zoology, and Zhang Weiqi's research group of the Beijing Institute of Genomics of the Chinese Academy of Sciences jointly published an online publication entitled "Destabilizing heterochromatin" in the journal Nature Aging .

The researchers found that the protein level of APOE was up-regulated in various human stem cell aging models, suggesting a potential link between APOE and the regulation of human stem cell aging

This study revealed for the first time a novel molecular mechanism by which APOE destroys heterochromatin structure and accelerates cell aging through the autophagy-lysosome pathway, expanding people's understanding of the novel biological function and mechanism of apolipoprotein APOE

The journal Nature Aging distributed News & Views at the same time, giving a positive evaluation of the research

The research was completed in cooperation with the Institute of Zoology, Chinese Academy of Sciences, the Institute of Stem Cell and Regenerative Medicine Innovation of the Chinese Academy of Sciences, the Beijing Institute of Stem Cell and Regenerative Medicine, the Beijing Institute of Genomics, Chinese Academy of Sciences, and Xuanwu Hospital of Capital Medical University

Links to the original text and comments:

https://https:// Nuclear-localized APOE promotes senescence in human stem cells

Figure: Commentary on Nature Aging's highlights during the same period