Chinese research shows that maternal obesity increases the risk of liver cancer in future generations.

Introduction: one third of the world's population is overweight or obese, and this global obesity is threatening human health.obesity increases the risk of metabolic diseases such as nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC).recently, researchers in China have found that maternal obesity can increase the risk of liver cancer in offspring.liver cancer is one of the most common cancers in the world and China. According to statistics, in 2018, there were about 840000 new cases of liver cancer and 780000 deaths in the world, and about half of the new cases and deaths caused by liver cancer were in China.recently, researchers in Wuhan have found a microRNA in obese mice, which seems to be susceptible to liver cancer, thus increasing the possibility of liver cancer development in their offspring and offspring.the study was jointly led by Dr. Zheng Ling of School of life sciences, Wuhan University, and Dr. Huang Kun, School of pharmacy, Tongji Medical College, Huazhong University of science and technology, and was published in the Journal of Hepatology on June 25.the title is "polygenerational maternall obesity increases the incidence of HCC in offspring via mir-27a-3p" previously, scientists have recognized the link between maternal obesity and liver cancer in their offspring, however, the mechanism is still unclear.in this new study, the researchers found a microRNA in the mothers of obese mice, which seemed to be susceptible to liver cancer, thus increasing the possibility of liver cancer development in their offspring and offspring.the researchers injected diethylnitrosamine (DEN) into obese mice fed a high-fat diet to induce liver cancer.RNA sequencing was performed to determine the changes in genes and microRNAs between generations.they found that microRNA mir-27a-3p injected into pregnant mice not only increased the expression of mir-27a-3p in liver, but also decreased the expression of two genes ACSL1 and ALDH2 in offspring (fetal, juvenile and adult). The down-regulation of ACSL1 and ALDH2 synergistically promoted cell proliferation (in vitro) or tumor growth (in vivo), and intensified the development of liver cancer in offspring of Den treated mice.maternal obesity induced by high-fat diet leads to the susceptibility of offspring to den induced liver cancer.the researchers confirmed that this susceptibility was cumulative from generation to generation.in addition, the risk of liver cancer increases from generation to generation.for example, offspring whose mothers and grandmothers are obese are more severe than those whose mothers are obese but whose grandmothers are normal weight.the chief researcher, Dr. Zheng Ling, School of life sciences, Wuhan University, and Dr. Huang Kun, from the school of pharmacy, Tongji Medical College, Huazhong University of science and technology, explained: "maternal obesity directly affects the health of offspring and plays an important role in the prevalence of obesity and metabolic diseases.epidemiological studies have shown that obesity is an independent risk factor for liver cancer. our research provides insights into whether maternal obesity is and whether it affects the incidence rate of cancer in offspring. "the researchers also analyzed human liver cancer samples. they found that in human hepatocellular carcinoma, up-regulation of mir-27a-3p and down-regulation of ACSL1 / ALDH2 were negatively correlated with survival. Professor Huang pointed out: "our findings reveal the mechanism between maternal obesity and the development of diseases in offspring, which will help to explore the treatment and prevention measures of fetal and developmental diseases. "for pregnant mothers, serum levels of mir-27a-3p are critical to the health of their offspring and may be used as diagnostic or predictive biomarkers in the future. therefore, we call for global efforts to address the problem of multiple generations of maternal obesity, so as to better address this common problem we are facing. In an accompanying editorial, Dr Sabine Colnot of INSERM umrs 1138 Cordeliers research center in Paris, France, and Dr. Andr é lechel, Department of internal medicine, University Hospital of Ulm, Germany, commented in an accompanying editorial: "this study opens up a new way for cancer research at the intersection of metabolism and epigenetics. it brings new information on how maternal stress affects their offspring and the development of liver cancer. this genetic pattern is not typical intergenerational inheritance. it is intergenerational, because the susceptibility to liver cancer increases over time. "Ref.: [1] Yu sun et al, multigenerational materal obexity increases the evidence of HCC in offspring via mir-27a-3p,  Journal of Hepatology (2020). DOI: 10.1016 / j.jhep. 2020.03.050 [2] [3] ා% 20 [4] recommended reading: fighting the epidemic situation, translational medicine network content team series report: [review] first comparison: the harm of cigarette, electronic cigarette and hookah to human body, especially to cardiovascular harm [science sub journal] new discovery: unique genetic variation of Brazilians will increase their risk of cancer [lancet] from 21 The study of 157436 people in the country shows that air pollution is a major factor contributing to cardiovascular diseases. Professor Zheng Limin shared the expression, regulation and clinical significance of PD-L1 in liver cancer tissues.