China's scientific research team found new targets for asthma treatment

Reporters recently learned from Changzhou University, Shanghai University of Traditional Chinese Medicine Professor Yang Yongqing research team and the university's Professor Deng Linhong research team, found a new target for asthma treatment - myoglobin binding protein 2 (Transgelin-2), which will be for the development of asthma treatment drugs and effective control of asthma, found a new path. The results of the research have been published in
international journals, and as cover articles.
, asthma is a serious threat to human health of common chronic respiratory diseases, China is the incidence of asthma, one of the highest fatality rate. In research and clinical, its pathological mechanism has not been determined.
Professor Deng Linhong's research team has long been devoted to the study of physiological pathological mechanisms of respiratory diseases such as asthma, and has made a series of important research achievements in the study of cell dynamic behavior at the micron scale, especially in cytostructure dynamics and cell response to mechanical stimuli.according to
, the scientific research team from the clinically effective treatment of needles against asthma, in the study found needle vertebrae, windgates, pulmonary pulmonary vertebrae and other points, can significantly improve the respiratory function of asthma patients, and improve the key role in asthma incidence of metal thioprotein-2 (MT-2) protein content. In cooperation with the Shanghai Institute of Pharmaceutical Research of the Chinese Academy of Sciences, using relevant techniques, small molecules that can be specific to the acupuncture anti-asthma target Transgelin-2 were screened from 6,000 compounds, and the pilot compound TSG12, which confirmed the smooth muscle action of the "needle-like" trachea, was verified to be a potential new anti-asthma drug with good clinical application prospects.
Deng Linhong told reporters that the study also proved that Transgelin-2 is active through the "calcium-sensitive" way to lyse the effect mechanism of the smooth muscle of the trachea. Transgelin-2 protein helps speed up the development of new asthma treatments. This is the first new target for bronchial asthma in China based on the discovery and verification of traditional Chinese medicine acupuncture in the treatment of asthma. (Source: Guozhong Dong Jin Rentao, Science and Technology Daily