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China Medical University: Protein Processing Disorders in Parkinson's Disease

 Last Update: 2021-10-22
 Source: Internet
 Author: User

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China Medical Zhan Xiao ni team published an article in Aging "proteomics characterized in dopaminergic neurons secrete granules showed Parkinson's disease chromogranin / secretory granules mediated impaired protein processing"
.

According to the report, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MTPT) was secreted in tyrosine hydroxylase-positive neurons in the substantia nigra and striatum of exposed mice The number of granules (SGs) and the marker protein secreted granulin III were significantly reduced

Dr.

Xiaoni Zhan of China Medical University said: "Parkinson's disease (PD) is the second most common age-related neurodegenerative disease

The results from electron microscopy studies show that in neurons and neuroendocrine cells, in addition to synaptic vesicles, there are a large number of dense core vesicles (DCVs), so-called secretory granules (SGs) or secretory vesicles
.

Abundant secretory granules were found in thalamic cortical axons, hippocampal glutamatergic neurons and striatal GABAergic neurons

Scg3 acts as a bridge between chromogranin a and cargo aggregates
.

It also participates in early peptide processing by interacting with carboxypeptidase E in the vesicle membrane

Secretogranins II (Scg2) and Secretogranins III (Scg3) are members of the Secretogranin family, which are a class of acidic secreted proteins that are abundantly expressed on SG
.

They are traditionally regarded as markers of SGs and regulated secretory pathways, and act as key molecules in the early accumulation and processing of peptide hormones in vesicles

In previous studies, researchers used paraquat (PQ) to establish a dopaminergic neurotoxin-induced Parkinson's disease (PD) model
.

They observed a significant reduction in the number of Scg3-positive SGs in dopaminergic SH-sy5y cells

Zhan Xiaoni's team purified SGs from dopaminergic SH-sy5Y cells in MPTP-induced Parkinson's disease (PD) mouse models, and conducted proteomic studies on them, and identified 536 significantly differentially expressed proteins
.

The results showed that inactivation of lysosomes and peroxisomes, lipid and energy metabolism disorders are the three main characteristics of PD

Full text-https:// Author: Zhan Xiaoni, Email: xnzhan@cmu.

edu.

Keywords: Parkinson's disease, secretory granule, secretory granule protein, proteomics, lipid metabolism, neuropeptide

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