China completes world's first genetically modified cloned rabbit experiment

China completed the world's first genetically modified cloned rabbit to today has survived for 3 monthsRecently in Shanghai through molecular biology identification, the results show that the experimental rabbit contains an external green fluorescent protein gene, proved that it is genetically modified cloned rabbitIt is reported that researchers in Shanghai XinhuaHospitalafter nearly a year of efforts to overcome the rabbit cell gene transfection, the establishment of genetically modified cell lines and the cloning of genetically modified cells, on September 14 this year successfully won the world's first genetically modified cloned rabbitThis genetically modified cloned rabbit carries the green fluorescent protein gene, which lays the foundation for the establishment of large-scale genetically modified rabbit animal model son in the futureThe study was carried out by the Center forDevelopmental Biology research at XinhuaHospital, affiliated with Shanghai Jiaotong University School of Medicine, in cooperation with the National Center for Molecular Genetic Breeding of Livestock and Livestock at the Beijing Institute of Livestock and Veterinary Research of the Chinese Academy of Agricultural SciencesOne of the leaders of the research team, Professor Du Lixin of the National Center for Molecular Genetic Breeding of Livestock and Poultry, said that the next step of the experiment is to carry out targeted integration of exogenous genes and to carry out genetically modified operations of functional genes, which has been fundedThe cloning of rabbits is a worldwide problemSince the birth of dolly, several teams around the world have started cloning rabbits, but only the French National Agricultural Research Institute reported in 2002 that cloned rabbits from sexually mature female rabbit granule cellsAccording to the researchers, rabbit is a widely used economic animal and experimental animal, and it has important research significance and economic value to modify the genome of rabbit by genetic targetingBecause rabbits and people are physically closer, the emergence of cloned rabbits can be used as a "animal model" to help humans screen drugs, study geneticsdisease
, and help to study some human geneticdiseases Previously, the team had used fetal rabbit fibroblasts to make a survival of cloned rabbits, is also the world's first Born in February this year, this body cell clone rabbit, using the pregnancy of 20 days of fetal rabbit back skin culture, and then the cultured cell embryo into the "surrogate" mother rabbit's fallopian tube, after the end of pregnancy through a caesarean section