Children's neo crown symptoms are not severe or related to blood vessels

the outbreak of neo-crown pneumonia, scientists have been trying to figure out why children are not as susceptible to serious complications as adults when infected with the virus. Earlier, a study published in The Lancet suggested that the answer may be hidden in the blood vessels of children's health.
only a small proportion of cases of new coronavirus infection. A large-scale survey by the U.S. Centers for Disease Control and Prevention found that children 17 and younger make up 22 percent of the U.S. population, but children 17 and younger make up less than 2 percent of new confirmed cases of coronary pneumonia in the United States. Of the 2,572 children surveyed, only 5.7 per cent went to hospital and only three died.
researchers have come up with several theories to explain why children's conditions are less severe: children have a stronger and more effective initial immune response to the virus than adults; But a growing number of researchers believe that differences between adults and children may stem from their vascular conditions.
many adults with severe neo-coronary pneumonia have a history of vascular coagulation, which can lead to heart attacks or strokes. Frank Ruschitzka, a cardiologist at the University Hospital Zurich in Switzerland, says clotting appears to be associated with the dis functioning of endoth endocytes, smooth tissue arranged on blood vessels that usually prevent clotting. Normally, blood clots are formed only to stop the bleeding, but if endoblasts are damaged, blood clots can also form.
Ruschitzka and colleagues found that the new coronavirus can infect endothellocytes throughout the body. In a study of three patients with neo-coronary pneumonia, two of whom died, the Ruschitzka team found that the new coronavirus infected the patient's endoblast cells, leading to signs of inflammation and clotting.
Ruschitzka said the study was small, so such complications needed further study, but the problem with endothellocytes appeared to be linked to the development of severe illness or death in most adult patients with neocytosis.
Marcel Levi, a hematologist at University College London Hospital, said the theory could also explain why people with diabetes and high blood pressure are at higher risk of developing severe diseases after contracting the new coronavirus, which can cause damage to the endothorl cells in patients.
children are usually in much better endothellular cell states than adults. Paul Monagle, paediatric hematologist at the Royal Children's Hospital in Melbourne, Australia, said: "The child's endothy tissue is in perfect condition and gets worse with age. According
Monagle and others, children's blood vessels are more resistant to virus attacks than adults. Another evidence to support this view, he says, is that very few children with new coronary pneumonia experience excessive clotting and damage to blood vessels.
Monagle is trying to understand what happens when a new coronavirus enters endoblast cells. He believes the new coronavirus may interfere with communication between cells, plateplates and plasma groups involved in clotting, leading to excessive clotting.
Monagle has launched two experiments to try to better understand the mechanism and see if something protects children's blood vessels from producing too many blood clots when the virus infects. In the first experiment, his team will try to reconstruct the in-vascular environment in children and adults in the lab. They will immerse endoblast cells infected with the new coronavirus in plasma from three sources - children, healthy adults and adults with vascular disease. By comparing how infected cells interact with three different types of plasma, we can further understand the causes of signaling errors in blood vessels.
Monagle hopes to learn more about what's going on in adults by studying samples from children. "If we understand the situation of children, we should be able to make adjustments to bring the situation of adults closer to that of children," he said. In
second experiment, his team will analyze the plasma of children and adults diagnosed with neocytitis to identify potential disease markers. These plasmas contain proteins released by damaged endothys. (Source: Xin Yu, China Science Daily)
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