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Recently, the research group of Chen Yan from Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences published a research result titled "Intermittent protein restriction protects islet beta cells and improves glucose homeostasis in diabetic mice" in the international academic journal Science Bulletin
.
The study found that intermittent protein restriction protects pancreatic beta cells and improves blood glucose homeostasis in diabetic mice
.
Diabetes, especially type 2 diabetes, has become one of the greatest health challenges facing humanity in the 21st century
.
Type 2 diabetes is often caused by an unhealthy life>
.
For example, the Mediterranean diet, which emphasizes plant-based foods and reduces animal-based foods, has been widely used in the management of type 2 diabetes
.
A recent study exploring the effects of three macronutrient ratios (i.
e.
, protein, fat, and carbohydrate) on the health of mice found that reducing protein intake is critical for improving metabolic health and longevity
.
Multiple studies have also found that reducing protein intake is an important factor in extending lifespan and improving metabolic health, and other studies have also found that limiting certain key amino acids such as methionine or leucine can also improve glucose homeostasis
.
In addition to protein- or amino-acid-restricted dietary strategies, fasting or caloric restriction has long been recognized as an effective means of extending lifespan and improving metabolic health
.
In recent years, many caloric restriction modalities such as intermittent dieting and time-restricted diet have been widely used to improve metabolic diseases including diabetes
.
Some studies have shown that intermittent fasting can effectively control blood glucose homeostasis in type 1 and type 2 diabetic mice, and some studies have revealed that intermittent fasting controls blood glucose homeostasis by promoting the regeneration of pancreatic β cells in diabetic mice
.
Although continuous protein or amino acid restriction and intermittent dieting have been shown to improve diabetes, no studies have examined whether intermittent protein restriction is sufficient to intervene in diabetes
.
This study investigated an intermittent protein restriction (IPR) diet and found that IPR rapidly alleviated hyperglycemia in STZ-induced type 1 diabetic mice and leptin receptor deficiency-induced type 2 diabetic mice
.
Further studies on mouse pancreatic islets found that IPR can increase the number of pancreatic beta cells, promote beta cell proliferation, and improve beta cell function
.
In peripheral tissues, IPR reduces hepatic gluconeogenesis and increases insulin sensitivity in skeletal muscle
.
Compared with a persistent low-protein diet, IPR was associated with less hepatic fat accumulation and damage in diabetic mice
.
In addition, single-cell sequencing analysis of mouse pancreatic islets found that IPR could reverse the diabetes-induced reduction in the number of islet beta cells and the infiltration of islet immune cells
.
Because IPR can effectively control blood sugar and protect islet beta cells, it may be more acceptable than fasting or calorie restriction, and avoid the adverse effects of persistent protein restriction, so IPR will have a greater application in the future.
potential
.
Researcher Chen Yan from Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences is the corresponding author of the paper, and doctoral students Wei Siying and Li Chenchen are the co-first authors of the paper
.
This work was supported by the Ministry of Science and Technology, the National Natural Science Foundation of China and other funds, as well as the public technology platform and animal platform of the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences
.
Figure: Intermittent protein restriction protects islet beta cells and improves glucose homeostasis in diabetic mice
.
The study found that intermittent protein restriction protects pancreatic beta cells and improves blood glucose homeostasis in diabetic mice
.
Diabetes, especially type 2 diabetes, has become one of the greatest health challenges facing humanity in the 21st century
.
Type 2 diabetes is often caused by an unhealthy life>
.
For example, the Mediterranean diet, which emphasizes plant-based foods and reduces animal-based foods, has been widely used in the management of type 2 diabetes
.
A recent study exploring the effects of three macronutrient ratios (i.
e.
, protein, fat, and carbohydrate) on the health of mice found that reducing protein intake is critical for improving metabolic health and longevity
.
Multiple studies have also found that reducing protein intake is an important factor in extending lifespan and improving metabolic health, and other studies have also found that limiting certain key amino acids such as methionine or leucine can also improve glucose homeostasis
.
In addition to protein- or amino-acid-restricted dietary strategies, fasting or caloric restriction has long been recognized as an effective means of extending lifespan and improving metabolic health
.
In recent years, many caloric restriction modalities such as intermittent dieting and time-restricted diet have been widely used to improve metabolic diseases including diabetes
.
Some studies have shown that intermittent fasting can effectively control blood glucose homeostasis in type 1 and type 2 diabetic mice, and some studies have revealed that intermittent fasting controls blood glucose homeostasis by promoting the regeneration of pancreatic β cells in diabetic mice
.
Although continuous protein or amino acid restriction and intermittent dieting have been shown to improve diabetes, no studies have examined whether intermittent protein restriction is sufficient to intervene in diabetes
.
This study investigated an intermittent protein restriction (IPR) diet and found that IPR rapidly alleviated hyperglycemia in STZ-induced type 1 diabetic mice and leptin receptor deficiency-induced type 2 diabetic mice
.
Further studies on mouse pancreatic islets found that IPR can increase the number of pancreatic beta cells, promote beta cell proliferation, and improve beta cell function
.
In peripheral tissues, IPR reduces hepatic gluconeogenesis and increases insulin sensitivity in skeletal muscle
.
Compared with a persistent low-protein diet, IPR was associated with less hepatic fat accumulation and damage in diabetic mice
.
In addition, single-cell sequencing analysis of mouse pancreatic islets found that IPR could reverse the diabetes-induced reduction in the number of islet beta cells and the infiltration of islet immune cells
.
Because IPR can effectively control blood sugar and protect islet beta cells, it may be more acceptable than fasting or calorie restriction, and avoid the adverse effects of persistent protein restriction, so IPR will have a greater application in the future.
potential
.
Researcher Chen Yan from Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences is the corresponding author of the paper, and doctoral students Wei Siying and Li Chenchen are the co-first authors of the paper
.
This work was supported by the Ministry of Science and Technology, the National Natural Science Foundation of China and other funds, as well as the public technology platform and animal platform of the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences
.
Figure: Intermittent protein restriction protects islet beta cells and improves glucose homeostasis in diabetic mice
