Chen Aerospace Research Group proposed the switching mechanism of TRIC ion channel

TRIC ion channels play an important physiological role in the human body, and their absence or mutation is also closely related to some diseases. The TRIC ion channel has two subsypes, TRIC-A and TRIC-B. The TRIC-A channel is a potential drug target for the treatment of malignant hypertension; Therefore, the study of the three-dimensional structure-function of TRIC ion channels will be of great significance to our understanding of calcium ion signals in tissues such as cardiomyocytes and skeletal muscle cells
bioinfoystic studies have found that TRIC ion channels are present not only in mammals, but also in primary nuclear organisms. Chen Aerospace Research Group completed the high-resolution three-dimensional structure of TRIC ion channels from ancient bacteria and bacteria and related functional analysis, and proposed the switching mechanism of TRIC ion channels. The study was published May 19, 2017 in the journal
. Su Min, a member of the Chen Aerospace Research Group, Mao Yang, a graduate student, Li Delin, a doctoral student, and Qi Yuan of the Andrew Marks Research Group are co-authors of the paper. The author of this communication is Chen Aerospace Researcher of the Institute of Genetic Development of the Chinese Academy of Sciences. The research was funded by the Chinese Academy of Sciences' strategic pilot project, the Ministry of Science and Technology's major research and development program and the National Natural Science Foundation of China. (Source: Science.com)