Chem Commun: New peptide molecules can be used to treat gastrointestinal disorders

July 8, 2020 /PRNewswire/ -- Biovalley BIOON/--- TFF1 peptides are key players in mucous membrane protection and repairIn a recent study, the team led by Markus Mutseler of the Department of Chemistry at the University of Vienna successfully synthesized and folded TFF1 peptides for the first timethree known trefoil family peptides TFF1, TFF2 and TFF3 are mainly produced by the gastrointestinal mucosaNamed after its three-leaf folding structureStudies have shown that these peptides, which are the product of local resistance to inflammation and gastrointestinal damage by accelerating wound healing, have great potential for treating gastrointestinal and other mucosa diseases such as dry eye disease and asthma(Photo:"So far, there are two oral peptide treatments on the market for diseases such as irritable bowel syndrome," Muttenthaler saidBecause the molecules are relatively large, they are not absorbed into the blood stream through the gastrointestinal wall and therefore only function locally in the gastrointestinal tract without serious side effectsIn their study, the researchers described the chemical synthesis of TFF1 and its hoe-like dipolymer, which contains two TFF1 subcellsTFF1 interacts with mucous proteins (the main structural components of the gastrointestinal tract) only in its homogenous form, thus accelerating the closure of the mucous membrane barrier and its healing processbecause it has up to 60 amino acids, the conventional method is not suitable for tFF1 synthesisTo this effect, the scientists developed a new way to synthesize two fragments and then assemble themThe correct folding is confirmed by structural analysis, and the interaction between TFF1 hopolymer and gastric mucosa is shownMuttenthaler and his team are now working on the chemical synthesis of TFF3 and the more challenging TFF2, two other members of the trilobite family, which has 106 amino acids and 7 dissulfur bonds, and is longer and more complexthe chemical synthesis ofTFF1 is a milestone in this field because it provides more options to modify this peptideTo date, recombinant expressions are the only way to produce these molecules, so their design is limited to 20 natural amino acidsChemical synthesis now enables us to design advanced TFF1 probes to study its mechanism of action or optimize the therapeutic application of TFF1Muttenthaler explainsFor more effective therapeutic applications, other modifications can be used to further improve the stability of peptides and the nature of similar drugs (Biovalley Bioon.com)source:Researchers develops peptides for treating gastrointestinal sacurasoriginal source:Emidio, NB., et al(2020) ChemicalSynthesis synthesis human to tre Chemical Communications.
doi.org/10.1039/D0CC02321C.