Characteristics of glioblastoma in adult cerebellum

The results were published online december 2017 in journal of Neuro-Oncology in 17 adult cerebellum GBM patients in retrospective studies, such as Thi?baud Picart of the Civilian Hospice Hospital in Lyon, France- Excerpted from the article: Picart T, et alJ Neurooncol2018 Feb; 136 (3): 555-563doi: 10.1007/s11060-017-2682-7Epub 2017 Dec 1glioblastoma (GBM) is extremely rare in adultsThe cerebellum weighs about 10% of the total brain, and some estimate that 10% of GBM occurs in the cerebellumHowever, the reported incidence of cerebellum GBM accounted for only 0.24%-4.1% of the total primary GBMTherefore, it is necessary to study the clinical characteristics of cerebellum GBM in a comprehensive studyThe results were published online december 2017 in journal of Neuro-Oncology in 17 adult cerebellum GBM patients in retrospective studies, such as Thi?baud Picart of the Civilian Hospice Hospital in Lyon, Franceresearchers retrieved detailed data from 17 patients with CEEs from a patient database at the University Hospital of Lyon and compared them with 103 patients with GBM on the screenThe average age of 17 cerebellum GBM diagnoses was 53.4 years3 cases have a history of type I neurofibromatoma10 cases (58.8%) were cerebellum GBM, 4 cases (23.5%) of GBM, 3 cases (17.7%) tired of hemispheric and b) GBM (Figure 1)H3 K27M mutation was found in 3 patients, 3 TERT promoter mutations, and 3 cases of MGMT promoter methylationNo patients were carrying EGFR amplification, IDH or BRAF mutationsNF1 and H3 K27M mutations appear to be mutually exclusive in the cerebellum GBMCompared to on-screen GBM, the incidence of CEEs tends to be more common in younger patients (53.4 to 63.2 years; p-0.02), with NF1 genes (18 vs1 ;p .009) and H3 K27M (21 It was associated with mutations of 3% ;p.02), and tumor diagnosis tended to be multi-disease performance (21 vs4.3 ;p;pThe total survival of patients with cerebellum GBM was short (5.9 months compared to 14.2 months; p.0.004)Figure 1MRI and histology characteristics of cerebellum GBMAPatients with cerebellum GBM (cases 2, 4, 12, 13 and 14), patients with GBM (1st, 6th and 16th) and multiple-cooker GBM patients (10th case); BCase of metastatic progression, lesions withmultiple synods within 4 months (11th case); CThe brain MRI-T2 image (left) and the T1 enhancement image of the spinal cord (centre) at the time of diagnosis showed the ;D of epidural dispersion (3rd case)Histology characteristics were highly polymorphic immersion atomostoma, microhevanoplasis, histone H3 K27M mutant protein immunohistamorphic strong staining (3rd)the study was limited by retrospective design, small sample size, lack of large-scale molecular characteristicanalysis and H3K36 trimethylation analysis, other molecular changes associated with epigenetic disorders could not be definedFrom available data, adult cerebellum GBM is different from on-screen GBM, which forms an IDH wild type with at least two subgroups, one group associated with H3 K27M mutations and the other with NF1.