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Changes to artificial blood substitute oxygenation rules

 Last Update: 2022-09-07
 Source: Internet
 Author: User

Porous fluid promises to be bridge therapy, game-changer for artificial blood substitutes, preservation of transplanted organs

What if first responders could treat patients in desperate need of oxygen with simple injections, rather than relying on mechanical ventilation or rushing them to heart-lung bypass machines?

A new method of transporting gases using porous liquid materials represents a big step toward artificial oxygen carriers and demonstrates the enormous potential of these unusual liquids for biomedicine

In a study published in the journal Nature in August, a team of scientists from Harvard University's Department of Chemistry and Chemical Biology details a new method for transporting gases using porous liquids in aqueous environments

"We realized that there would be many benefits to using liquids with permanent microporosity to solve gas transport problems in water and other aqueous environments," said Jarad Mason, assistant professor of chemistry and chemical biology, senior author on the paper

This design makes the inner surface waterproof and the outer surface hydrophilic "because otherwise the fluid would phase separate like oil and water"

Liquids with permanent micropores are a new class of materials composed of microporous particles dispersed in a liquid medium

Water is a polar molecule, which makes it an excellent solvent for other polar molecules such as ethanol and sugar, but it is far worse at dissolving non-polar molecules such as O2 gas

The researchers suspended microporous nanocrystals in water and other aqueous solutions

Inspired by certain protein pores that can be contacted by water molecules but remain generally dry in aqueous solutions, the team proposes that microporous nanocrystals with a hydrophobic inner surface and a hydrophilic outer surface can be engineered to make microporous The frame dries permanently in water and can absorb gas molecules

"We had to reconcile two seemingly contradictory properties," Erdosy said

The team synthesized the materials in the lab and tested their ability to absorb and release gases

The lab plans to conduct more experiments with microporous water to test its biomedical applications, while continuing to explore other potential uses for the material

"We hope to develop more materials and animal models to create and test oxygen carriers in vivo," Erdosy said.

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