Cell: uncover how human cells respond to external environmental signals and process them

July 5, 2019 / BIOON / - recently, in a research report published in the international journal Cell, scientists from Heidelberg University and other institutions analyzed how human cells react to external signals and process them by using new biotechnology methods In this paper, the researchers focus on the interaction between G protein and its receptor GPCRs G protein is the mediator of signal transmission, while GPCRs can induce signal process Photo source: Thomas splattstoesser (www.sci-style Com) researchers say they can not only better understand the interaction between gpcrs-g proteins, but also effectively predict the function of the two All organisms can respond to external signals from the environment In humans and other animals, these signals can be detected and processed by receptors (coupled with G protein) in the cell membrane GPCRs is the largest transmembrane receptor family, which can react to a large number of extracellular physical and chemical signals and induce special processes in cells One of the methods is to In this study, the researchers conducted in-depth study and Analysis on these coupling processes There are 16 kinds of G proteins in human body, which can be coupled with nearly 1000 kinds of GPCRs Using biotechnology tools and machine learning methods, researchers can conduct in-depth research on 148 representative receptors and 11 kinds of proteins to understand the interaction between gpcrs-g proteins Then researchers uncovered the coupling events between hundreds of gpcrs-g proteins, which may help to understand GPCRs Working mechanism Based on the results of this study, now researchers can better predict the coupling between gpcrs-g proteins than ever before, and can also design artificial GPCRs that are ultimately used for biomedical research and carry special signal characteristics; researchers speculate that better understanding of the interaction between gpcrs-g proteins will have an impact on the later development of new drugs to treat a variety of human diseases Very important significance and value Original sources: Inoue a, Raimondi F, Kadji FMN, et al Illuminating G-protein-coupling selectivity of GPCRs Cell 2019 Jun 13; 177 (7): 1933-1947.e25 Doi: 10.1016/j.cell.2019.04.044