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Cell: The surprising new function of immune cells in the brain

 Last Update: 2021-09-29
 Source: Internet
 Author: User

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Picture: (blue: cell nucleus) can be combined by tubular projection (red) to degrade dangerous proteins

AG Heneka/University of Bonn

In order to break down toxic proteins faster, immune cells in the brain can join together to form a network when needed

Alpha-synuclein (abbreviated as aSyn) performs important tasks in brain nerve cells

Therefore, the brain's immune cells, microglia, try to break down and process aSyn aggregates

Division of labor can prevent overload

Studies have shown that microglia may join together spontaneously to better respond to threats

Among the more common mutations in some Parkinson's disease patients, both aSyn and mitochondrial transport are impaired

The fact that microglia can join together is unknown in the past

Article highlights

• Microglia quickly swallow exogenous α-synuclein but slowly degrade it

Article Abstract

Original search:

DOI

10.

Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

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