Cell sub-magazine in-depth interpretation! Adult stem cell steady state and aging circadian rhythm regulation mechanism!

, June 29, 2020 /
PRNewswire/ -- Scientist
s from the Academy of Science and Technology in Barcelona, Spain, have revealed thesteady state ofadult stem cells, based on a study published in theof the international journalCell Stem CellCircadian clock sage irregular mechanisms with aging; circadian clocks organize the body's cell physiologic activity throughout the day, allowing daily environmental changes to be predicted while temporarily separating potentially harmful physiological processes; and by synchronizing all cells at the tissue level, circadian clocks ensure consistent tempru physiological characteristics of the bodyA recent study of adultstem cellphysiological characteristics shows that aging andstem cellscircadian rhythms are closely intertwinedreview article, the researchers revealed the mechanismby by which circadian clocks regulate the function of adult stem cells, and how changes in circadian clocks during aging regulate the internal and external mechanisms that determine the steady state of adult stem cellsIn the article, the researchers discussed "circadian rhythms and habitats of adult stem cells," "circadian rhythm system clues in adult stem cell habitats," "Aging and circadian rhythms of adult stem cells," "Aging systematic circadian rhythm networks," "Interference of circadian rhythms, and the aging of adultstem cells." Photo Credit: Salvador Aznar Benitah, et al Cell Stem Cell doi:10.1016/j.stem.2020.05.002
recent research on adult stem cell circadian clocks reveals the importance of circadian rhythm clocks for stem cell function, and results show that the time of adult stem cell physiology mediated by circadian clocks Tissue is essential to maintain the steady state of body tissues and stem cells, and the output of transcription/translation oscillation systems and circadian rhythms appears to be adapted to the need
for each adult
stem cell chamber of the young organism to maintain a specific steady state; interestingly, it seems that not all adult stem cell chambers establish transcription altrue oscillation patterns of the core clock machine, even if the components of circadian clocks are expressed in most stem cells; The development of circadian rhythm transcription oscillation patterns during the process; at present, researchers do not know the background and physiological causes of this difference, and the transcriptional inhibition of embryonic stem cells and clock protein expression in the fetal heart is associated with the function of the absence of circadian rhythms in these undifferentiated cells, and the release of this inhibition may be related to the differentiation process Interestingly, inducing the oscillation of pluripotent stem cells circadian clock during in vitro B cell differentiation may induce changes in epigenetics, which in turn promotes the maturation of engineered islet cells, revealing that the establishment of stem cell functional biological clocks is an important step toward smaturation and maturation, and later researchers will study the importance of revealing the functional clock stakes in different adult stem cell chambers, while also determining which cells can help determine the functional signals that help determine the function of the clock However, it is important that even in stem cell populations that lack an oscillating clock, researchers were able to observe daily physiological rhythms, which suggested that in these cells, circadian clocks can be established by clues that are dependent on habitats, non-transcriptal clues, or circadian clocks; An example of circadian rhythm dependence, in which the circadian light cycle is sufficient to sustain the oscillation of genes involved in translation and oxidation phosphorylation regulation, and researchers are still not sure whether adult the physiological properties of stem cell and aging are affected by the regulation of daily rhythms on which circadian clocks depend in peripheral tissues, circadian rhythm strains appear to be used only as an oscillator to allow upstream synchronous environmental cues (such as light, food intake, metabolism, temperature, mechanical cues, etc.) to coordinate downstream tempo physiological characteristics accordingly; For example, reducing autonomic nerve dominance, altering body fluid cues, increasing the stiffness of The ECM) or causing the robustness of the oscillator in peripheral tissues and adult stem cells, which in turn reduces the ability of the biological clock to respond to changes in environmental conditions and potentially impairs the different strides of the clock between different peripheral tissues and adult stem cells , and later researchers need to further study the effects of these aging-related interferences the output of circadian rhythms is important for maintaining the steady state and proper daily tissue function of adult stem cells, and it is critical that, although the bioclock output of young mice mainly deals with the internal balance function of specific tissues or adult stem cells chambers, in older mouse organisms, a new set of genes usually becomes rhythmic and participates in tissue-specific and stress-related responses Researchers don't yet know the molecular mechanisms of age-related circadian rhythm reprogramming, although epigenetic genetic factors, stress, or age-induced transcription and post-transcription regulators are candidates for altering the output of the biological clock finally, circadian rhythms are mostly measured through a single gene reporting system or at transcription levels, taking into account the complex post-transcription regulation mechanisms of circadian rhythm clocks, assessing the state of the core clock at protein levels and protein modification levels, and measuring the circadian rhythms of the metable and microbiome groups, which are essential for late-stage scientists to understand how circadian rhythm clocks affect the function of tissues and adult stem cells during the aging phase (BioValleyBioon.com) references: Salvador Aznar Benitah, Patrick-Simon Welz Circadian Regulation of The Adult Stem Cell Homeostasis and Aging , Cell Cell Cell (2020) doi: 10.1016/j.stem.stem.2020.05.002
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