CELL STEM CELL: Lipid metabolism found to control brain development for the first time
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Last Update: 2020-05-30
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Source: Internet
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Author: User
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Changes in neurostem/progenitor cell (NSPC) activity and neurodevelopmental deficiencies are associated with intellectual disabilityHowever, it is not clear whether changes in metabolism, the key regulator for NSPC activity, can disrupt human neurodevelopment and lead to possible cognitive impairmentsrecently, in the expression of mutant fatty acid synthase (FASN; In mice and human embryonic stem cells (hESCs) of R1819W, the link between lipid metabolism and cognitive function was studiedFASN is a metabolic regulator recently identified in humans with intellectual disabilitiesIn pure-bond mice with FASN R1812W variants, the accumulation of lipids in NSPCs and subsequent lipid ER stress led to impaired activity and cognitive impairment in adult hippocampusThe NSPCs derived from the same type FASN R1819W hESC showed a decrease in proliferation rate in embryonic two-dimensional culture and three-dimensional pre-brain regionalized organs, consistent with developmental phenotypesdata from adult mouse models and in vitro models of human brain development showed that changes in lipid metabolism affect cognitive impairment
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