Cell Stem Cell: Blocking the biosynthesis of proteins or the ability to inhibit cancer stem cells

May 17, 2020 News /BiovalleyBIOON / - tumor cells are not all uniform, like colon cancer to contain differentiated cells (which similar functional cell wall) and a so-called cancer stem cells in a (pluripotent cells), a tumor stem cells promote a growth of a tumor a study and lead to cancer metastasis, recently, one published in the international Journal ofCellStemCell, scientists from the Barcelona Institute of Medicine and other institutions on the adoption study found that colon cancerdryplurality of potential nature is its ability to synthesize proteins in cells, and this feature or researcher can be used as a target for the development of new anticancer therapySource: IRBBarcelonaresearchers Batlle said that the current colon cancer therapy is not very effective because the treatment does not remove all of pluripotent cells, several studies found that, when a cancer stem cell to remove a by experimental means, other differentiated cells will return to a pluripotent state and reproducing a tumor, this phenomenon researchers call it plasticitythis study, researchers observed that protein synthesis can occur in that particular region of the tumor cancer stem cells consistent habitat, in addition, tumors can also exhibit a gradient exhibition protein production, once the consumption activity is make tumor cells will irreversibly lose its ability to return to a cancer stem cell state, so this will make the biosynthetic ability of cancer stem cells indefinitely promote tumor growthThe researchers said this paper can help us, or based on function rather than personality to clear the cancer stem cells, the researchers will next investigate the possibility of in-depth study by therapeutic interventiontumor stem cellsbiosynthesisability to block tumor growth and metastasisThe researchers explainedClaraMorral, using a mouse model of colon cancer study, we observed, by blocking protein synthesis or eliminate a cancer cell cancer cell protein synthesis, you may be able to order a species in an irreversible manner to block tumor growth, the next step will be in-depth study investigator tumor environment how special signal or mediated tumor cell specific biosynthesis ability to maintain this study, researchers used to study organ class, that cultivate in the laboratory of tumor tissues derived from patients with mini body, it may be able to help researchers study the heterogeneity of tumor cells and organization; organoid culture system is also a powerful tool that can simulate the characteristics of the cancer in a patient's body is found, in addition, studies described herein, researchers also investigated the use of CRISPR-Cas9 tumor cells
genetically modified conditions, the technology can help researchers specifically includes Clear biosynthesis of tumor cells, while the contributions analyzed promoting growth of tumor (Biovalley Bioon.com) Original source: ClaraMorra, JelenaStanisavljevic, XavierHernando-Momblona, ​​etal ZonationofRibosomalDNATranscriptionDefinesaStemCellHierarchyinColorectalCancer , CellStemCell (2020) .doi: 10.1016 / j.stem.2020.04.012