Cell review sit-up deep interpretation! How does breast milk regulate intergenerational immune inheritance?

, June 28, 2020 /PRNewswire/
-- The colon, called ROR-T-t-regulatory Tcells (Tregs), inhibits excessive body inflammatory responses, but also slows the body's removal of pathogens, and researchers do not yet know the molecular mechanisms
in which these cells are regulated; In a reviewthe title "Breast Milk Modulates Transgenerational Immune", scientists from the University of Bern revealed the molecular mechanisms of breast milk to regulate intergenerational immune genetics, and found that at a critical time after birth, the set point of ROR-T-cells may have non-genetic maternalgeneticcharacteristics through the immune globulin A (IgA) in breast milkthe gut immune system faces a unique challenge of how to contain and produce a suitable response to the intestinal flora, the huge microbial population in the lower part of the intestine can be separated by a layer of epithelial cells and mucous membrane tissue, the immune mechanism is often fully balanced with the ability to eliminate invasive or sticky gastrointestinal pathogens, regulatory Tcells (Tregs) are induced by the intestinal flora It relies on transcription-regulating retinal receptors associated with retinoacid receptors,""cMaf, which limit inflammation but slow the removal rate of pathogens, and this regulatory pathway needs to function in the newborn body to ensure that the microbiome can survive and reproduce in its bodyIn this study, the researchers revealed a model of maternalgeneticthat isnon-
genetic, non-
epigenetics, which determines the abundance of ROR-t-T-Tregs cells in future generationsto ensure that the observed maternal genetics are based ongenetictransmission orepigeneticimprints, the researchers conducted a series of experiments to transfer the cubs from female mice with a genetic background to mammals with different genetic backgrounds, and it is worth noting that the phenotypes of ROR-t-Tregs are largely determined by nursing mothers, suggesting that most of them are non-genetic
, so that the influence of nursing mothers may be affectedPhoto Credit Jakob Zimmermann, et al.
Cell(2020) doi:10.1016/j.cell.2020.05.030
what mechanism is it to mediate the effect of breastfeeding on the ROR-T-T-Tregs cell setpoint? The researchers found that the removal of the microbial communityantibioticsduring lactation often required the biomass of microorganisms to eliminate the propagation effects, and consistent with the view that the levels of ROR-t-T-Tregs cells known to be significantly reduced in sterile mice were significantly reduced, and that a specific group of microorganisms was able to mediate this induced effect,ROR-γt+ Tregs
,,
。researchers are now building on the key role of mother-borne antibodies in the mother-borne non-hereditary transmission process, and by focusing on immune variables of ROR-t-T-Tregs cell characteristics, the researchers have revealed that antibodies (IgA) play a key role in the mother-borne non-genegeneticprocess, and the proportion of ROR-t-Tregs cells may have a negative correlation with the response of the intestinal IgA during lactation One possible explanation is that IgA in breast milk contains specific intestinal flora, and it limits the induction of local mucosa immunity in the breast-feeding offspring, so that negative feedback from each other may affect the reaction strain of IgA and ROR-T-T-Tregs, which may be relatively beneficial to IgA's response, or that this inhibition may be short-lived in nature, and that IgA reaction in the offspring may eventually be promoted by the parent's origin IgA researchers have proposed a model in which intestinal immunomodulation is achieved by two seemingly redundant mutual suppression systems, IgA antibodies and ROR-T-T-Tregs cells, where inflammatory stimulation determines whether it is IgA-hi (pathogen removal, type 3 inflammation) or ROR-T-T-type Treg-hi (type 2 inflammation, the targeting of pathogenic microorganisms), and due to the lack of proper immune regulation mechanisms, it would be interesting to determine the extent or extent of the range of mice with IgA and ROR-t-Tregs gene defects in the microbial microbiome environment IgA/ROR-γt+ Treg
,,。 This new regulatory feedback loop lies between slow and long-lasting chromosomal evolution and rapid and transient adaptive immune adjustment, and many immune advances determine the long-term process of host-microbial interaction (BioValleyBioon.com) References: Jakob Zimmermann, Andrew J Macpherson Milk Milk Milk Immunes Transmonby Inheritance , Cell
(2020) doi: 10.1016/j.cell.2020.05.030
.