Cell: Reveals the characteristics of systemic inflammation and antibody response in children with multi-system inflammatory syndrome.

September 23, 2020 /--- -- The new coronavirus SARS-CoV-2, which causes coronavirus disease (COVID-19) in 2019, is now raging around the world.
there is an urgent need for an effective vaccine against the virus.
, however, there is currently no human vaccine against SARS-CoV-2, but about 120 vaccine candidates are under development.
SARS-CoV-2 is associated with two other closely related highly pathogenic viruses, SARS-CoV and MERS-CoV.
SARS-CoV-2 has a just, single-stranded RNA genome of 30kb in size.
its nucleoproteins (N) and outer membranes consisting of membrane proteins (M), envelope proteins (E) and hedgehog proteins (S) enshrine its genome.
, it was thought that children were protected from diseases caused by the coronavirus SARS-CoV-2.
, a month after the outbreak, a new type of coVID-19-related multisystem inflammatory syndrome (multisystem inflammatory syndrome in children, MIS-C) emerged.
composition and structure of the SARS-Cov-2 genome, pictured is Molecular Cancer, 2020, doi:10.1186/s12943-020-01218-1.
a new study, researchers from the Icahn School of Medicine at Mount Sinai reported immune characteristics of nine MIS-C cases.
all MIS-C patients have evidence of previous exposure to SARS-CoV-2, triggering a complete and nalising antibody response.
results were published online September 14, 2020 in the journal Cell, under the title "Mapping Systems And Antibody Responses in MultisystemSysySysy Syndrome in Children (MIS-C)."
analysis of cytokines in these MIS-C patients identified elevated characteristics of inflammation (IL-18 and IL-6), lymphocyte and myelin cell activation and activation (CCL3, CCL4, and CDCP1), and mucosal immunodeficiration (IL-17A, CCL20, CCL28).
esotype analysis of external peritonal blood showed a decrease in non-classical monocytes, NK cells, and T lymphocyte sub-groups.
, the researchers dissected the autoantigen reactivity of plasma in MIS-C patients and found known disease-related autoantibodies (anti-La antibodies) and new candidate antibodies that identify endoskin, gastrointestinal and immune cell antigens.
all MIS-C patients were treated with anti-IL6R antibodies and/or IVIG, resulting in rapid remission.
(bioon.com) Reference: Conor Gruber et al. Mapping Systemic Explain and Antibody Responses in MultisystemSystemSy Syndrome in Children (MIS-C). Cell, 2020, doi:10.1016/j.cell.2020.09.034.