Cell Rep: Unleash Molecular "Brake" to Promote Cancer Immunotherapy

2020 May 19 News / BioValley BIOON / --- according to a new study recently published in the "CellReports" magazine, miRNA molecules can act as a "brake" regulate the activity of immune cells , which in turn remain dormantarticle author DrConnieKrawczyk said: "These miRNA plays an important role in the on / off state of the balance of the immune system." "Our findings reveal new insights into the immune function, hope that the future may one day use this knowledge to optimize the vaccine or immunotherapy against a variety of diseases "
(source: Www.pixabay.com)the body's immune response by many different cells and the chemical composition of these components in cells and resist pathogens, remove abnormal cells (such as cancer) and start the healing process has a respective effectIn the absence of threat, immune cells must be kept ready but not "activated" stateMicroRNA constitute a part of this complex defense systemThese RNA molecules can be rapid regulation of gene expression, and thus directly affect the immune responseKrawczyk and her colleagues found that a single microRNA can regulate multiple genes responsible for a particular cell type, but almost no effect on another cell type, this adaptation can fine-tune the immune response and to ensure that the correct immune cells deployed in the correct positionSpecific miRNAe.g., called microRNA-9 can help to maintain the cell by regulating the sleep state "brake" to adjust the active and dormant dendritic cellsUpon activation, microRNA-9 will release "brake", to allow normal operation of the cell(Biovalley Bioon.com) Information Source:Releasingmolecular'brake'kick-startsimmunecellfunctionOriginal source:BrendanCordeiroetal, MicroRNA-9Fine- TunesDendriticCellFunctionbySuppressingNegativeRegulatorsinaCell-Type-SpecificManner, CellReports (2020) .DOI: 10.1016 / j.celrep.2020.107585