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    Home > Active Ingredient News > Antitumor Therapy > Cell Rep: Lack of oxygen is the cause of cancer metastasis! "Oxygen therapy" or the key to cancer treatment.

    Cell Rep: Lack of oxygen is the cause of cancer metastasis! "Oxygen therapy" or the key to cancer treatment.

    • Last Update: 2020-09-25
    • Source: Internet
    • Author: User
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    A new study published in Cell Reports has found that hypoxia causes the separation and spread of tumor tissue that is otherwise clustered.
    that developing treatments to reduce hypoxia in tumors could create new opportunities for tumor metastasis in passivated patients! Metastasis is one of the manifestations of many advanced cancers and the most difficult to cure.
    then, the patient's cancer cells' ability to adhere is reduced or even completely lost, while their ability to migrate increases, causing cancer cells to move from the native site to other parts of the body with the blood or lymphatic system, forming new tumors.
    is even more frightening, in which case the patient is sentenced to death, almost incurable.
    previous studies have shown that circulating tumor cells (CTCs) are the source of tumor metastasis - circulating tumor cells that fall off the tumor and circulate with the blood.
    , however, the specific mechanisms that trigger the shedding of circulating tumor cells in primary cancer lesions are not yet fully relevant.
    recently, Nicola Aceto of the Cancer Metastasis Laboratory at the University of Basel in Switzerland and others published a research paper entitled Hypoxia Triggers the Intravasation of Clustered Sourced Tumor Cells in cell sub-journal.
    study showed that lack of oxygen in tumors led to the formation of clustered circulatory tumor cells (CTCs) with high metastasis capacity.
    , the use of angiogenesic therapy can effectively prevent the production of circulating tumor cells (CTCs) clusters, thereby inhibiting tumor metastasis.
    Hypoxia activates a gene in tumor tissue called HIF1 (hypoxia-inducing factor) whose expression products can reduce or even shut down the oxygen consumption process in mitochondrials, especially oxidation phosphate, making glycolysis the main energy production method for cancer cells.
    2019 Nobel Prize in Physiology or Medicine was awarded to the three founders who discovered the HIF1 path.
    cell Reports study, researchers analyzed oxygen supply within tumors, separation of circulating tumor cells (CTCs), and their molecular and cellular biological properties in a mouse model of breast cancer.
    the experimental design schematics of this study, researchers found that when breast cancer cells were dynamically labeled along the progression of cancer, we observed that most circulating tumor cells (CTCs) clusters were hypoxia-deprived, while most of the single circulating tumor cells (CTCs) were in a normal oxygen state.
    team found oxygen-deprived cancer cells in areas of tumors with relatively few blood vessels.
    , the researchers studied isolated clusters of circulating tumor cells (CTCs) and found that they were also oxygen-deprived.
    , they speculate that if cancer cells don't get enough oxygen, they will leave tumor tissue and metaspose to spread elsewhere.
    , Nicola Aceto, the study's co-author, explains: "It's like crowding too many people in a small space, so some people go outside and breathe fresh air."
    " dynamic marking of hypooxygenic CTCs and further observations of their metastasis potential showed that oxygen-deprived circulating tumor cells (CTCs) clusters metasposed more quickly than normal oxygen-containing circulating tumor cell (CTCs) clusters, greatly reducing the survival time of mice.
    It is worth noting that the study also found that targeted inhibitory endosthort growth factor (VEGF) can lead to the contraction of primary tumors, but at the same time, it also increases the hypoxia environment within the tumor, inducing more circulating tumor cells (CTCs) cluster shedding and metastasis formation.
    , angiogenesic therapy increases the size of primary tumors, but it also significantly inhibits the formation and metastasis of circulating tumor cell (CTCs) clusters.
    seems to be a very contradictory result, and if the tumor is given enough oxygen, there is no reason for the cancer cells to metasn by metastasis.
    on the other hand, enough oxygen will accelerate the growth of primary tumors.
    VEGFA targets increased CTC cluster shedding and metastasis formation, but in any case, the discovery of the new mechanism represents another step closer to conquering cancer in humans! Nicola Aceto's team said it would look forward to the new findings to be applied to the clinical treatment of patients with different characteristics, which will guide the development of more advanced and effective cancer treatment drugs and treatment options.
    Nicola Aceto and others concluded: "We speculate that treatments aimed at reducing hypoxia in tumors, whether treated alone or in a coalition with anticancer drugs, may provide a new opportunity to blunt the metastatic spread of breast cancer patients and other types of cancer."
    " In addition, in November 2019, researchers at Johns Hopkins University School of Medicine published a research paper in the journal Nature Communications entitled Fate-mapping post-hypoxic tumor cells revealss a ROS-resistant phenotype that promotes metastasis.
    The study showed that cells experiencing hypoxia in the body had different gene expression patterns than cells exposed to hypoxia in vitro, and that exposure to chronic hypoxia gave cancer cells a stronger esoteric, metastasis, and ROS-resistant esoteric physiology, which promoted their survival and was more likely to spread to other parts of the body.
    , both studies have shown that hypoxia in tumors is the cause of cancer cell metastasis, and that "oxygen therapy" may be key to treating metastasis cancers.
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