Cell: New cancer immunotherapy based on nanobiology may be expected to cure cancer once and for all

November 3, 2020 // -- In a recent study published in the international journal Cell, scientists from Mount Sinai Hospital and other institutions made significant progress in the development of new cancer immunotherapy by pairing nano-bio-micromaterials with therapeutic ingredients produced by bioengineering natural molecules and then training the body's congenital immune system to destroy tumor cells.
researchers say the nanobiological immunotherapy targets the bone marrow, where part of the immune system forms, and activates the body's trained immunity, a process that reprograms bone marrow pregenitor cells to produce trained congenital immune cells that inhibit cancer progression, and cancer cells often protect themselves from the host immune system with the help of the body's immunosuppressive cells.
researchers believe that trained immunity can be safely and successfully used as a cancer treatment, and that they have been tested in animal models, including melanoma mouse models, and are now actively moving toward clinical trials.
Photo Source: CC0 Public Domain immunotherapy is part of a standard cancer treatment that exposes the host immune system to cancer, but it has limitations, such as immunosuppressant therapy, which works only for a limited number of patients and can have serious therapeutic side effects. In the
study, researchers developed a new type of anti-cancer therapy, which they say can be trained as an independent anti-cancer therapy and does not have multiple side effects, and can be used in combination with checkpoint inhibitor drugs. 'Not only have we observed the powerful anti-cancer effects of nanobiological immunotherapy, but this work has also led to the development and preclinical evaluation of new immunotherapy based on high biocompaciate nanomaterials,' said
researcher Professor Willem J. Mulder.
the study changed the rules of immunotherapy research, and later researchers will continue to delve into developing more effective new treatments for cancer, the researchers said.
() Original source: Bram Priem, Mandy M. T. van Leent, Abraham J. P. Teunissen, et al. Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumors Growth and Potentiates Checkpoint Rement, Cell (2020). doi:10.1016/j.cell.2020.09.059