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Picture: Clusters of long-lived mitochondria in neurons
Mitochondria are called the cell's power station, which produces energy and fuels the functions of our cells
Martin Hetzer, senior author of the paper and senior vice president and chief scientific officer of Salk, said: "For a long time, people have been concerned about how specific cells in various tissues are maintained throughout their life cycles.
The Hetzer laboratory uses genetic methods and advanced imaging techniques to study how tissue is maintained and repaired throughout its life cycle
Based on previous work, Salk's Hetzer team and UCSD colleagues collaborated to conduct a more in-depth study of mitochondria in mouse brain cells
In the mitochondria, the researchers decided to focus on the protein that is part of the electron transport chain, which is essential for the main function of the mitochondria to generate energy
"We were surprised to find that some mitochondrial proteins are still very stable and turn much slower than most proteins," said first author Shefali Krishna (Shefali Krishna), a worker in Heizer's laboratory.
To further understand why these long-lived mitochondrial proteins can survive for so long, they studied what happens if the protein's mRNA is exhausted, which contains the instructions to make more protein
"Synthesizing new proteins is very energy intensive, so from the perspective of energy conservation, it makes sense to have long-lived proteins," Hetzer said
"I like to use a car as an analogy; it has some parts that need to be replaced frequently, such as oil and tires, and some parts that take a long time to use, such as the engine
"This work provides another powerful example of how to study the lifespan of different cell components and organelles through the application of new high-resolution imaging techniques," co-author and UCSD professor Mark Ellisman (Mark Ellisman) Say
The research team plans to continue to study these long-lived proteins in mitochondria to further clarify the role of mitochondria in aging diseases
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