Cell Journal: Improving the fidelity of protein synthesis can prolong life

At present, people's researches on biological aging and diseases are endless, but most of them focus on DNA mutations, while the research and understanding of the role of translation errors are scarce

The imbalance of protein homeostasis is a key factor in aging and age-related diseases, and translation is one of its key determinants

On September 14, 2021, Ivana Bjedov, Filipe Cabreiro and other researchers from University College London, UK, jointly published an online article entitled "Improving the Fidelity of Protein Synthesis and Prolonging Life" in the journal Cell Metabolism

The fidelity of protein translation is determined by the ribosome decoding center

The experimental results show that the translation accuracy of RPS23 K60R fruit flies is improved compared with the control group

Subsequently, the research team explored the physiological consequences of this mutation in yeast, worms and flies

Mutant RPS23 K60R has heat tolerance and developmental delay

Finally, the researchers raised the question of whether improving the fidelity of translation can promote the longevity of single-cell and multicellular organisms

In addition, researchers found that anti-aging drugs such as rapamycin, Torin1 and trametinib can reduce translation errors, and rapamycin can further extend the biological life of the RPS23 ultra-precision mutant

Experimental mechanism diagram

In summary, this article has conducted a phylogenetic analysis of the key protein RPS23 in the ribosome decoding center, and introduced the eukaryotic RPS23 homologue

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https:// the fidelity of protein synthesis can prolong lifespan