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Immunofluorescence images showing T cells (blue) attack tumor cells (white) by forming immune synapses with LFA-1 (open head conformation - marked in red)
Magnesium levels in the blood are an important factor in the immune system's ability to fight off pathogens and cancer cells
Magnesium deficiency has been linked to a variety of diseases, such as infections and cancer
Now, researchers led by Professor Christoph Hess from the Departments of Biomedical Sciences at the University of Basel, the University Hospital of Basel and the Department of Medicine at the University of Cambridge have found that T cells are only able to effectively eliminate abnormal or infected cells in a magnesium-rich environment
As a docking site, LFA-1 plays a key role in the activation of T cells
Potentially important discovery for cancer patients
The fact that magnesium is essential for T cell function may be a very important discovery in modern cancer immunotherapy
"In order to validate this observation clinically, we are now looking for ways to specifically increase the concentration of magnesium in tumors," said Christoph Hess
Based on the available data, the question of whether regular intake of magnesium affects the risk of cancer cannot be answered
Magazine
Cell
DOI
10.
Article Title
Magnesium sensing via LFA-1 regulates CD8+ T cell effector function
