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Rift Valley Fever virus has caused economically devastating outbreaks of hemorrhagic fever in livestock such as sheep, goats and cattle
There is currently no specific treatment for Rift Valley fever, which is limited to Africa and the Arabian Peninsula
Researchers at the Washington University School of Medicine in St.
Dr.
The World Health Organization has listed Rift Valley Fever as a priority disease that may cause an epidemic in the near future
To find out how the virus invaded cells, the first author Dr.
This discovery constitutes an opportunity
The researchers infected a group of mice with the virus and treated them with RAP
RAP itself is not a good prospect for drug development, because it is a normal mammalian protein that plays a role in many important biological processes
"This discovery is the key to understanding how the Rift Valley fever virus not only spreads throughout the human body, but also how it infects mosquitoes and different kinds of mammals
The discovery that the Rift Valley fever virus uses LRP1 to enter cells is interesting because the role of this protein in cholesterol metabolism is better known
Original search:
Lrp1 is a host entry factor for Rift Valley Fever Virus
DOI
10.
