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Mouse embryonic stem cells that undergo electrochemical specialization are labeled with nuclei (blue) and neuronal processes (red)
.
The new research team at the Dresden University of Technology aims to reveal how stem cells respond to mechanical forces and electrical signals during the development and maintenance of the nervous and cardiovascular systems
.
Dr.
Adele Doyle, an assistant professor at the University of California, Santa Barbara, joined the Life Physics Cluster (PoL) in July 2021, leading the Stem Cell Mechanobiology Research Group at the University of Dresden
.
Using the methods of engineering, biology, and computer science, her group studies how molecular circuits make special mechanical signal transmission possible
Cells in organisms are surrounded by physical signals, such as mechanical force, material properties, electrical signals, and chemical signals
.
Depending on the function of the cells and the surrounding environment, they experience different material properties and mechanical force inputs of different sizes and dynamics
The goal of the Doyle laboratory is to help cell and regenerative medicine therapies become the standard treatment options for patients with debilitating and chronic diseases
.
The team's expertise is mainly focused on the nervous and cardiovascular systems, and they also pay attention to the needs of patients
In order to study how mechanical signals affect embryonic development and biological homeostasis, Adele Doyle and her research team designed experimental methods to perform more precise and sensitive molecular measurements in living cells, and developed new computational tools to analyze experimental data.
Simulate how cells make decisions
.
They also work with engineering and micromanufacturing groups to study how controlled physical inputs affect cell behavior, such as in the case of traumatic brain injury
"Our research is at the interface between physical sciences such as engineering and physics, natural sciences such as chemistry and biology, medicine and computer science
.
We combine three main aspects: technological development, and the mechanical biology of stem cells and their descendants.
In order to meet these needs, the smooth transfer of knowledge and expertise within and between research groups and institutes is essential
.
The Physics of Life (PoL) cluster forms a network between disciplines and is committed to this type of collaborative research
Adele Doyle received a bachelor's degree in biomedical engineering from Washington University in St.
Louis, USA
.
She received her PhD in Biomedical Engineering from Georgia Institute of Technology and Emory University in 2010
