Cell Death Dis: The therapeutic effect of carbapenems on chronic ulcerative colitis

Ulcerative colitis (UC) is a difficult-to-treat chronic inflammatory bowel disease (IBD) characterized by severe diarrhea, abnormal weight loss, stool blood, abdominal pain and fatigueTHE INFLAMMATORY REACTION OF UC IS MAINLY FOUND IN THE MUCOUS MEMBRANE AND THE LOWER MUCOUS MEMBRANE OF THE COLON AND RECTAL, AND ITS PATHOGENESIS MECHANISM IS VARIED AND CORRELATED WITH GENETIC SUSCEPTIBILITY, IMMUNE SYSTEM IMBALANCE, INTESTINAL BARRIER DYSFUNCTION AND MICROBIAL DISORDERAlthough berberine, an heteroquine alkaloid, has been shown to have a protective effect on experimental colitis, its potential molecular mechanisms in chronic enteritis remain unclearthe study reveals the therapeutic efficacy and immunomodulation of amynolycedinininin in chronic UCresearchers studied the therapeutic effects of taking asmalline in a dSS(sodium glucansulsulfate)-induced chronic UC mouse model and further validated its underlying mechanism by transfection of human intestinal matrix cells by si-OSMRstudies have found that the aphorite can significantly reduce the clinical symptoms of chronic UC and the inflammatory response of the intestineThe treatment of the small carbapenem can also maintain intestinal barrier function and improve tissue fibrosisIn combination with the leaching reaction of antigen-presenting cells (APC), congenital lymphocytic cells (ILC) and activated NK cells in the colon's inherent layer, osM and OSMR were found to have elevated expression levels and reduced therapeutic effect of carbapenems in chronic UC inflammatory tissueIn addition, the small palate can inhibit the overactivation of human intestinal matrix cells by regulating the OSM-mediated JAK-STAT pathway, which is significantly inhibited after using siRNA that targets OSMRthe study revealed the treatment mechanisms of the carbapenem sylline and found that interventions in OSM and OSMR may be potential treatment strategies for chronic UC