【CELL DEATH DIS】 The Southern Medical University team revealed for the first time the role of Myo1b in the regulation of autophagy and angiogenesis in colon cancer cells

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Author: Mia

There is growing evidence that dysregulation of Myo1b (myosin 1b) expression has been extensively studied
in the development and progression of several tumors.
Recently, a research team has elucidated for the first time the role of Myo1b in autophagy regulation and angiogenesis in colon cancer cells, and revealed that it may be a viable predictive biomarker and therapeutic target
.

Recently, Yihong Chen, Nanzhu Xu, Chang Hong of Southern Medical University as the first authors, and Professor Jueyu Zhou as the corresponding author, published a report entitled "Myo1b promotes tumor progression and angiogenesis by inhibiting autophagic degradation of HIF-1α in colorectal" in Cell Death & Disease cancer"
.
This study found the potential function of Myo1b in colorectal cancer, and confirmed that Myo1b promotes colorectal cancer progression and angiogenesis by inhibiting the autophagy degradation of HIF-1α, suggesting that Myo1b has the role of
tumor promoting factor in colorectal cancer.

https://doi.
org/10.
1038/s41419-022-05397-1

Research background

 01 

Colorectal cancer (CRC) is the third most common cancer and second leading cause of cancer-related death worldwide, and its incidence is rising
rapidly among young and middle-aged adults.
Despite the availability of standard treatments including surgery, radiotherapy, and chemotherapy, there is currently no effective and reliable means to improve the survival rate
of patients with advanced colorectal cancer.
In addition, tumor-induced angiogenesis is a key marker of tumorigenesis and the cause of cancer cell growth and metastasis in CRC, so targeted antiangiogenic therapy is a promising option
for CRC therapy.

In recent years, there is new evidence that myosin is an important regulator of tumorigenesis and plays a role
in causing or suppressing tumors.
Myo1b is an important member of class I myosin and is involved in many key physiological and pathological processes
.
Abnormal expression of Myo1b has been detected in a variety of cancers, including prostate cancer, head and neck squamous cell carcinoma (HNSCC), cervical cancer, esophageal cancer (ESCC), and glioma, but research on the role of Myo1b in CRC tumorigenesis is still limited and its mechanism of action is unclear
.

Molecular mechanisms by which Myo1b promotes angiogenesis