Cell Death Dis: RASSF1A inhibits the deterioration of nasopharyngeal cancer through YAP1 dependence

Nasopharyngeal cancer (NPC) is a highly invasive tumor.
in head and neck cancer, nasopharyngeal cancer has the highest metastasis rate, and patients with far-end metastasis have a higher rate of treatment failure.
stem cells (CSCs) are small cells that reside in tumors.
NPC's CSC has the ability to renew, differentiate and cause tumors, and has been proven to be the main cause of drug resistance, tumor recurrence and metastasis.
previous studies have shown that the absence or lower expression level of RASSF1A is a key event in the development of NPC.
, however, raSSF1A is still little known about the role or potential mechanism of malignant esopaedics of the disease.
the level of expression of RASSF1A was associated with self-renewal and tumor-ogenogenization of nasopharyngeal cancer cells in the study, the researchers found that the expression of RASSF1A inhibited the malignancy of NPC cells.
in NPC cell line, stable silent RASSF1A induces cell self-renewal and tumor-inducing, and improves cell invasion.
mechanism studies have shown that RASSF1A can be reshaped by mediating actin, inactivated YAP1, a transcriptional activation factor, and further promotes transcription inhibition of PDGFB.
PDGFB therapy can inhibit the expression level of YAP1 for a short period of time and partially increase the malignancy of NPC cells.
rasSF1A reshaped infrastetrically infrastethed YAP1 by mediating myoproteins, the results show that RASSF1A is able to inhibit PDGFB expression and inhibit NPC deterioration by YAP1 dependence.
, PDGFB may be a potential therapeutic target for metastasis NPC patients.